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Front. Neurol. | doi: 10.3389/fneur.2018.00107

Gray Matter and White Matter Abnormalities in Temporal Lobe Epilepsy Patients with and without Hippocampal Sclerosis

  • 1National Center of Neurology and Psychiatry (Japan), Japan
  • 2College of Life Science and Bioengineering, Beijing University of Technology, China

ABSTRACT
The presentation and distribution of gray matter (GM) and white matter (WM) abnormalities in temporal lobe epilepsy (TLE) have been widely studied. Here, we investigated the GM and WM abnormalities in TLE patients with and without HS in five groups of participants: healthy controls (n = 28), right TLE patients with HS (n = 26), right TLE patients without HS (n = 30), left TLE patients with HS (n = 25), and left TLE patients without HS (n = 27). We performed a flexible factorial statistical test in a voxel-based morphometry analysis to identify significant GM and WM abnormalities and analysis of variance of hippocampal and amygdala regions among the five groups using the FreeSurfer procedure. Furthermore, we conducted multiple regression analysis to assess regional GM and WM changes with disease duration. We observed significant ipsilateral mesiotemporal GM and WM volume reductions in TLE patients with HS compared with healthy controls. We also observed a slight GM amygdala swelling in right TLE patients without HS. The regression analysis revealed significant negative GM and WM changes with disease duration specifically in left TLE patients with HS. The observed GM and WM abnormalities may contribute to our understanding of the root of epilepsy mechanisms and act as biomarkers for patient monitoring.

Keywords: Temporal Lobe Epilepsy, Hippocampal Sclerosis, voxel-based morphometry, FreeSurfer, Magnetic Resonance Imaging

Received: 15 Aug 2017; Accepted: 13 Feb 2018.

Edited by:

Fernando Cendes, Universidade Estadual de Campinas, Brazil

Reviewed by:

Luiz Eduardo Betting, Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Brazil
Marino M. Bianchin, Federal University of Rio Grande do Sul (UFRGS), Brazil  

Copyright: © 2018 Beheshti, Sone, Farokhian, Maikusa and Matsuda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mr. Iman Beheshti, National Center of Neurology and Psychiatry (Japan), Tokyo, Japan, iman.beheshti@cc.emu.edu.tr