AUTHOR=Berman Brian D. , Pollard Rebecca Tran , Shelton Erika , Karki Ramesh , Smith-Jones Peter M. , Miao Yubin TITLE=GABAA Receptor Availability Changes Underlie Symptoms in Isolated Cervical Dystonia JOURNAL=Frontiers in Neurology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2018.00188 DOI=10.3389/fneur.2018.00188 ISSN=1664-2295 ABSTRACT=
GABAA receptor availability changes within sensorimotor regions have been reported in some isolated forms of dystonia. Whether similar abnormalities underlie symptoms in cervical dystonia is not known. In the present study, a total of 15 cervical dystonia patients and 15 age- and sex-matched controls underwent 11C-flumazenil PET/CT scanning. The density of available GABAA receptors was estimated using a Simplified Reference Tissue Model 2. Group differences were evaluated using a two-sample