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Systematic Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.00940

Impaired social cognition in epilepsy

Hennric Jokeit1 and  Victoria Ives-Deliperi2*
  • 1Neuropsychology, Swiss Epilepsy Center, Switzerland
  • 2University of Cape Town, South Africa

Background: Social cognition refers to specific mental processes that subserve social interaction. Impaired social cognition has been increasingly reported in patients with epilepsy and impacts negatively on overall quality of life. In this article, we will review neuroimaging studies of social cognition in people with epilepsy. Method: An electronic search of the literature was conducted and 14 studies qualified for inclusion in the review. Results: Although the studies reviewed revealed a varied pattern of neural activations in response to emotion recognition and theory of mind tasks, consensual findings included altered pattern of signal activation in the social cognition network in patients with mesial temporal lobe epilepsy compared to healthy controls and significantly reduced signal activations and functional connectivity within this network in patients with right mesial temporal lobe pathology. Conclusion: This review contextualises our current understanding of the pathophysiology of impaired social cognition in epilepsy and makes recommendations for further research.

Keywords: Neuroimaging, Epilepsy, fMRI, social cognition, review

Received: 14 May 2019; Accepted: 14 Aug 2019.

Edited by:

Britta Wandschneider, Institute of Neurology, Faculty of Brain Sciences, University College London, United Kingdom

Reviewed by:

Mario A. Alonso Vanegas, HMG Hospital Coyoacán, Mexico
Stefano Meletti, Department of Biomedical Sciences, Metabolism, and Neuroscience. University of Modena and Reggio Emilia, NOCSE Hospital  

Copyright: © 2019 Jokeit and Ives-Deliperi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Victoria Ives-Deliperi, University of Cape Town, Cape Town, South Africa, vickideliperi@icloud.com