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Front. Neurol. | doi: 10.3389/fneur.2019.01123

The role of glutamate transporter in drug addiction: a target for addiction

Wenjun Wang1, 2, Fancai Zeng2, Yingying' Hu2 and  Xiang Li3*
  • 1School of Basic Medical Science , luzhou , China, China
  • 2School of Basic Medical Science, China
  • 3School of Basic Medical Sciences, Southwest Medical University, China

The development of new treatment for drug abuse requires identification of targetable molecular mechanisms. The pathology of glutamate neurotransmission system in the brain reward circuit is related to the relapse of multiple drugs. Glutamate transporter regulates glutamate signaling by removing excess glutamate from the synapse. The aim of this review is to highlight the effects of drug addiction on glutamate transporter and glutamate uptake, and targeting glutamate transporter as an addictive drug addiction treatment.

Keywords: Addiction, glutamate transporters, excitatory amino acid transporters, Vesicular glutamate transporters, Glutamate

Received: 02 Apr 2019; Accepted: 08 Oct 2019.

Copyright: © 2019 Wang, Zeng, Hu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Xiang Li, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China, lix2009@126.com