@ARTICLE{10.3389/fneur.2021.653483, AUTHOR={Helsper, Moritz and Agarwal, Aashish and Aker, Ahmet and Herten, Annika and Darkwah-Oppong, Marvin and Gembruch, Oliver and Deuschl, Cornelius and Forsting, Michael and Dammann, Philipp and Pierscianek, Daniela and Jabbarli, Ramazan and Sure, Ulrich and Wrede, Karsten Henning}, TITLE={The Subarachnoid Hemorrhage–Weather Myth: A Long-Term Big Data and Deep Learning Analysis}, JOURNAL={Frontiers in Neurology}, VOLUME={12}, YEAR={2021}, URL={https://www.frontiersin.org/articles/10.3389/fneur.2021.653483}, DOI={10.3389/fneur.2021.653483}, ISSN={1664-2295}, ABSTRACT={Objective: The frequency of aneurysmal subarachnoid hemorrhage (aSAH) presents complex fluctuations that have been attributed to weather and climate changes in the past. In the present long-term big data and deep learning analysis, we have addressed this long-held myth.Methods: Bleeding dates and basic demographic data for all consecutive patients (n = 1,271) admitted to our vascular center for treatment of aSAH between January 2003 and May 2020 (6,334 days) were collected from our continuously maintained database. The meteorological data of the local weather station, including 13 different weather and climate parameters, were retrieved from Germany's National Meteorological Service for the same period. Six different deep learning models were programmed using the Keras framework and were trained for aSAH event prediction with meteorological data from January 2003 to June 2017, with 10% of this dataset applied for data validation and model improvement. The dataset from July 2017 to May 2020 was tested for aSAH event prediction accuracy for all six models using the area under the receiver operating characteristic curve (AUROC) as the metric.Results: The study group comprised of 422 (33.2%) male and 849 (66.8%) female patients with an average age of 55 ± 14 years. None of the models showed an AUROC larger than 60.2. From the presented data, the influence of weather and climate on the occurrence of aSAH events is extremely unlikely.Conclusion: The myth of special weather conditions influencing the frequency of aSAH is disenchanted by this long-term big data and deep learning analysis.} }