Acute positional vertigo in the emergency department—peripheral vs. central positional nystagmus

Introduction Benign paroxysmal positional vertigo (BPPV) is the most common cause of positional vertigo. However, positional vertigo can also be due to diseases affecting the central vestibular pathways, such as vestibular migraine. Accurate and timely diagnosis enables effective triage and management. Objectives To evaluate diagnoses made by emergency clinicians compared to acute vertigo specialists, in patients presenting to an emergency department (ED) with positional vertigo. Methods Following routine ED care, patients with a primary complaint of dizziness, vertigo, light-headedness or unsteadiness, underwent detailed neuro-otological assessment by acute vertigo specialists. Demographics and final diagnoses were recorded and analyzed. Results Of 71 consented patients (21−91 years; mean 56 years, ±16.7 years, 40 females), ED identified 13 with a peripheral cause of positional vertigo (mean 48.85 years, ±16.19, 8 females). Central positional nystagmus was not noted in any of the patients with positional vertigo seen by the ED clinicians. Acute vertigo specialists diagnosed nine patients with BPPV (age range 50-88 years, mean 66 years, ±12.22, 5 females), and six with central positional nystagmus (age range 23−59 years, mean 41.67 years, ±15.78, 6 females). Conclusion Positional vertigo should be assessed with positional maneuvers such as Dix-Hallpike and Roll tests in the ED to identify peripheral and central nystagmus features. Central causes are more common in younger females, with the presence of vomiting, and/or a background of motion sensitivity.


Introduction
Positional vertigo is a symptom that is triggered by the act of moving the head to a new position (1).It can be due to peripheral (inner ear) or central causes, and have either a persistent or paroxysmal presentation (2).Benign paroxysmal positional vertigo (BPPV) is considered the most common peripheral cause for positional vertigo (3) and is due to otoconial debris becoming displaced from the maculae into a semicircular canal.It affects all age groups, but peaks in the sixth decade (4).It is characterized by brief vertigo and triggered by changes in head position against gravity.Conversely, central positional nystagmus (CPN) is attributed to disease affecting the central nervous system and is an important differential diagnosis to BPPV.CPN has been reported in a range of neurological disorders (5), including multiple sclerosis (6), cerebellar disease (7), and cerebellar stroke (8), with the commonest central cause being vestibular migraine (VM) particularly during an attack (9,10).
The pathophysiology of CPN is poorly understood but it is thought be due to an impaired integration of semicircular canals and central vestibular pathways in the cerebellum and brainstem and consequently providing a poor estimation of head tilt and/or eye position coordinates (9).Features of CPN include: (a) nystagmus that is atypical for BPPV is observed in the positional maneuvers, (b) the nystagmus fails to resolve with treatment, (c) additional neurological or ocular motor symptoms signs may be present (5,9).This highlights the importance of completing positional tests and an oculomotor assessment to differentiate central from peripheral causes (2,11,12), preferably with nystagmus documentation using video oculography.
Misclassification of the signs in patients with acute positional vertigo presenting to the ED has the potential to lead to misdiagnosis and mismanagement.Identifying the clinical presentations and signs in patients with positional vertigo, particularly in those with atypical positional nystagmus can help early and accurate identification of peripheral or central causes of acute positional vertigo.This will ensure appropriate repositioning maneuvers are completed when the cause is peripheral (BPPV can be quickly diagnosed and managed in the ED), and effective timely triage and management when central.
The aim of this article is to define the proportion of adults attending a single tertiary United Kingdom emergency department with positional dizziness or vertigo and identify the prevalence of BPPV versus central positional nystagmus, including vestibular migraine.We present the diagnoses made by both the ED clinicians and acute vertigo specialists.Furthermore, we describe the CPN features and clinical characteristics that aid the identification of central versus peripheral causes of positional vertigo.

Method
A prospective observational descriptive study was conducted on patients with a primary complaint of 'dizziness' , 'unsteadiness' , 'lightheadedness' , or 'vertigo' attending the ED of University College London Hospitals in the United Kingdom between January 2022 and December 2022.We included adult (18-90 yrs) patients who were able to consent.Patients with pre-existing dizziness and vertigo before attending the ED were not included.Ethical approval was obtained from the United Kingdom Northwest-Greater Manchester South Research Ethics Committee (approval No. 21/ NW/0015).This is a sub-study of a larger research project, for which a manuscript is under preparation.
Initial ED assessment was performed by a resident neurologist or emergency physician, under direct consultant supervision.Such assessment typically includes a full clinical history and general medical and neurological assessment, but may not always include HINTS-plus or positional maneuvers.Acute vertigo specialists were a neurologist (DK) with expertise in neuro-otology, and a Clinical Scientist in Neuro-audiology (NK) with expertise in audiovestibular science, with a combined experience of over 20 years in the field.All consented patients underwent the ED routine care and were later seen by the acute vertigo specialists.Neuro-otological assessments were performed by the specialist no later than 5 days of symptom onset.To exclude the presence of any associated signs, clinical examination that included spontaneous nystagmus, saccades, pursuit, bedside and video head impulse test, and Dix-Hallpike and Roll positional tests, with and without videonystagmography goggles (ICS Impulse; Natus, Denmark) were performed.All patients underwent computerized magnetic resonance imaging of the brain with diffusion angiography, T1, T2, and fluid-attenuated inversion recovery no later than 72 h of admission as part of the research study protocol, to systematically screen for central causes.
Continuous data is reported as means and standard deviations, categorical data presented as counts and proportions, and with p-values and z-scores calculated.

Results
A total of 71 adults presented to the ED reporting 'dizziness' , 'unsteadiness' , 'light-headedness' , or 'vertigo' were consented and able to be seen by the acute vertigo specialist team.Age range for the whole group was 21-91 years (mean 56 years, ±16.76 years), with more females (40 females to 31 males).
ED diagnosed 13 patients (age range 26 to 80 years, mean 48.85 years, ±16.19, 8 females) with a peripheral positional cause (i.e., BPPV), with no documentation of side or affected canal.CPN was not noted in any of the patients seen by the ED clinicians.Figure 1 shows those diagnosed by ED with a peripheral positional cause and the final diagnoses made by the acute vertigo specialists.
ED clinicians completed diagnostic positional maneuvers in 20% (n = 14) of the whole cohort, and specialists in 99% (n = 70).Of the 13 patients (18% of total cohort) that ED clinicians diagnosed as BPPV, the Dix-Hallpike test was completed only in seven.Of these seven, five were reported as having a positive Dix-Hallpike (of whom three patients received treatment repositioning manoeuvrers), and two were given a diagnosis of 'resolved' BPPV (the Dix-Hallpike was reported as negative in these two patients).Six patients (out of 13) were diagnosed with BPPV without positional maneuvers being performed on them.
Acute vertigo specialists diagnosed nine patients with a peripheral cause of positional vertigo, four with posterior canal BPPV, two with horizontal canal BPPV, and three resolved BPPV after ED performed repositioning maneuvers (age range 50 to 88 years, mean 66 years, ±12.22, 5 females), and six with a central cause of positional vertigo with apparent CPN (age range 23 to 59 years, mean 41.67 years, ±15.78, 6 females).The difference in ages was statistically significant between peripheral and central groups (older in the BPPV group, p = 0.005), and females between diagnoses (more females in the CPN group, p = 0.024).
Acute vertigo specialists detected CPN in six patients with acute positional vertigo, all of whom had a clinical diagnosis of vestibular migraine.The nystagmus features are summarized in Figure 2.
The MRI did not show any structural lesions in any of the patients with positional vertigo assessed by the acute specialists.Other vestibular and oculomotor examinations including spontaneous nystagmus, saccades, pursuit, and head impulse test were unremarkable (Table 1).

Discussion
This study investigated patients presenting to an ED with acute dizziness or vertigo, focusing on positional nystagmus.The diagnoses made by the ED clinicians were compared to the diagnoses made by the acute vertigo specialists.
ED diagnosed peripheral causes of positional vertigo (i.e., BPPV) in 18% of the total cohort, with no patients diagnosed with central causes of acute positional vertigo.While this proportion of patients diagnosed with BPPV in ED in this study is comparable to that previously reported (13), the ED clinicians completed positional maneuvers in just seven of the 13 patients they diagnosed with BPPV, with some maneuvers reported as negative despite a final diagnosis of BPPV.In addition, only three of those that ED diagnosed with BPPV went on to have confirmed BPPV diagnosis by the acute vertigo specialists (Figure 1).These  Of 71 consented patients, acute vertigo specialists identified six patients with CPN, confirmed and documented by videonystagmography-oculography during the positional tests.When Although we acknowledge the small sample size of this patient group with acute positional vertigo, salient clinical messages are apparent: (i) the somewhat lower prevalence of acute BPPV in patients with acute positional vertigo in the ED when central causes are also considered, (ii) VM may be the commonest cause of acute central positional vertigo in the ED, (iii) CPN caused by VM is more common than BPPV in younger females (<60 yrs) and those with a background of motion sensitivity, and (iv) vomiting is not a common feature of BPPV so a central cause should be suspected in patients with positional vertigo and vomiting.Larger trials are of course encouraged to validate these findings.
In summary, positional vertigo is more likely to be due to a central cause in younger females, with the presence of vomiting, and/or a background of motion sensitivity.This study reinforces the need for diagnostic positional tests in ED in patients with positional vertigo.This would allow diagnosis to be reached faster, with potential longerterm benefits for patient outcomes, and would also obviate the need for additional investigations and onward referrals.

FIGURE 2
FIGURE 2Proportion of peripheral and central causes of positional vertigo made by acute vertigo specialists, and features of CPN.CPN, central positional nystagmus; BPPV, benign paroxysmal positional vertigo; SPV, slow phase velocity.

TABLE 1
Characteristics (the presenting complaint, triggers, duration, associated symptoms and vascular risk factors) of the patients diagnosed by specialists with either peripheral (BPPV) or central positional (VM) diagnoses.comparisons are calculated and presented as p = values and z = scores.NS, not significant.Bold font indicates statistical significance. Weighted