AUTHOR=Willment Kim C., Golby Alexandra TITLE=Hemispheric Lateralization Interrupted: Material-Specific Memory Deficits in Temporal Lobe Epilepsy JOURNAL=Frontiers in Human Neuroscience VOLUME=7 YEAR=2013 URL=https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2013.00546 DOI=10.3389/fnhum.2013.00546 ISSN=1662-5161 ABSTRACT=

The hemispheric lateralization of memory has largely been informed through the study of patients with temporal lobe epilepsy originating from medial temporal sources (mTLE). The material-specific model of memory relies on the basic framework that the left temporal lobe mediates verbal memories, while the right temporal lobe mediates non-verbal memories. Over the years, this model has been refined, and even challenged, as our understanding of the material-specific memory deficits in mTLE has been further elaborated in the neuropsychological and neuroimaging literature. The first goal of this mini-review is to highlight the major findings in the mTLE literature that have advanced and expanded our understanding of material-specific memory deficits in mTLE. Second, we will review how functional neuroimaging patterns of material-specific hemispheric lateralization in mTLE are being translated into the innovative clinical application of preoperative fMRI memory mapping.