%A Tschernegg,Melanie %A Crone,Julia Sophia %A Eigenberger,Tina %A Schwartenbeck,Philipp %A Fauth-Bühler,Mira %A Leménager,Tagrid %A Mann,Karl %A Thon,Natasha %A Wurst,Friedrich %A Kronbichler,Martin %D 2013 %J Frontiers in Human Neuroscience %C %F %G English %K fMRI,graph theory,network,connectivity,Pathological Gambling,Reward,behavioral addiction,small world %Q %R 10.3389/fnhum.2013.00625 %W %L %M %P %7 %8 2013-September-27 %9 Original Research %+ Dr Martin Kronbichler,Centre for Neurocognitive Research and Department of Psychology, University of Salzburg,Salzburg,Austria,martin.kronbichler@sbg.ac.at %+ Dr Martin Kronbichler,Neuroscience Institute and Centre for Neurocognitive Research, Christian-Doppler-Klinik, Paracelsus Medical University Salzburg,Salzburg,Austria,martin.kronbichler@sbg.ac.at %# %! Brain Networks in Pathological Gambling %* %< %T Abnormalities of functional brain networks in pathological gambling: a graph-theoretical approach %U https://www.frontiersin.org/articles/10.3389/fnhum.2013.00625 %V 7 %0 JOURNAL ARTICLE %@ 1662-5161 %X Functional neuroimaging studies of pathological gambling (PG) demonstrate alterations in frontal and subcortical regions of the mesolimbic reward system. However, most investigations were performed using tasks involving reward processing or executive functions. Little is known about brain network abnormalities during task-free resting state in PG. In the present study, graph-theoretical methods were used to investigate network properties of resting state functional magnetic resonance imaging data in PG. We compared 19 patients with PG to 19 healthy controls (HCs) using the Graph Analysis Toolbox (GAT). None of the examined global metrics differed between groups. At the nodal level, pathological gambler showed a reduced clustering coefficient in the left paracingulate cortex and the left juxtapositional lobe (supplementary motor area, SMA), reduced local efficiency in the left SMA, as well as an increased node betweenness for the left and right paracingulate cortex and the left SMA. At an uncorrected threshold level, the node betweenness in the left inferior frontal gyrus was decreased and increased in the caudate. Additionally, increased functional connectivity between fronto-striatal regions and within frontal regions has also been found for the gambling patients. These findings suggest that regions associated with the reward system demonstrate reduced segregation but enhanced integration while regions associated with executive functions demonstrate reduced integration. The present study makes evident that PG is also associated with abnormalities in the topological network structure of the brain during rest. Since alterations in PG cannot be explained by direct effects of abused substances on the brain, these findings will be of relevance for understanding functional connectivity in other addictive disorders.