AUTHOR=Cacciola Alberto , Milardi Demetrio , Anastasi Giuseppe P. , Basile Gianpaolo A. , Ciolli Pietro , Irrera Mariangela , Cutroneo Giuseppina , Bruschetta Daniele , Rizzo Giuseppina , Mondello Stefania , Bramanti Placido , Quartarone Angelo TITLE=A Direct Cortico-Nigral Pathway as Revealed by Constrained Spherical Deconvolution Tractography in Humans JOURNAL=Frontiers in Human Neuroscience VOLUME=10 YEAR=2016 URL=https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2016.00374 DOI=10.3389/fnhum.2016.00374 ISSN=1662-5161 ABSTRACT=
Substantia nigra is an important neuronal structure, located in the ventral midbrain, that exerts a regulatory function within the basal ganglia circuitry through the nigro-striatal pathway. Although its subcortical connections are relatively well-known in human brain, little is known about its cortical connections. The existence of a direct cortico-nigral pathway has been demonstrated in rodents and primates but only hypothesized in humans. In this study, we aimed at evaluating cortical connections of substantia nigra