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Front. Hum. Neurosci. | doi: 10.3389/fnhum.2018.00168

Associations between Daily Mood States with Brain Gray Matter Volume, Resting-state Functional Connectivity and Task-based Activity in Healthy Adults

 Elmira Ismaylova1, 2,  Jessica Di Sante1, 2, 3, Jean-Philippe Gouin3,  Florence B. Pomares1, 3, Frank Vitaro1, 4, Richard E. Tremblay1, 5, 6 and  Linda Booij1, 2, 3*
  • 1CHU Sainte-Justine Research Center, Université de Montréal, Canada
  • 2Psychiatry, Université de Montréal, Canada
  • 3Psychology, Concordia University, Canada
  • 4School of Psychoeducation, Université de Montréal, Canada
  • 5Psychology and Pediatrics, Université de Montréal, Canada
  • 6School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland

Numerous studies have shown differences in the functioning in the areas of the frontal-limbic circuitry between depressed patients and controls. However, current knowledge on frontal-limbic neural substrates of individual differences in mood states in everyday life in healthy individuals is scarce. The present study investigates anatomical, resting-state and functional neural correlates of daily mood states in healthy individuals. We expected to observe associations between mood and the frontal-limbic circuitry and the default-mode network [DMN]. Forty-two healthy adults (19 men, 23 women; 34 ± 1.2 years) regularly followed for behavior and psychosocial functioning since age 6, underwent an fMRI scan and completed a daily diary of mood states and related cognitions for five consecutive days. Results showed that individuals with smaller left hippocampal gray matter volumes experienced more negative mood and rumination in their daily life. Greater resting-state functional connectivity [rsFC] within the DMN, namely between posterior cingulate cortex [PCC] and medial prefrontal cortical [MPFC] regions as well as between PCC and precuneus, was associated with both greater negative and positive mood states in daily life. These rsFC results could be indicative of the role of the DMN regional functioning in emotional arousal, irrespective of valence. Lastly, greater daily positive mood was associated with greater activation in response to negative emotional stimuli in the precentral gyri, previously linked to emotional interference on cognitive control. Altogether, present findings might reflect neural mechanisms underlying daily affect and cognition among healthy individuals.

Keywords: daily mood, fMRI, left hippocampus, default-mode Network, emotion

Received: 22 Dec 2017; Accepted: 11 Apr 2018.

Edited by:

Guido Van Wingen, University of Amsterdam, Netherlands

Reviewed by:

Scott A. Langenecker, University of Illinois at Chicago, United States
Ilya M. Veer, Charité Universitätsmedizin Berlin, Germany  

Copyright: © 2018 Ismaylova, Di Sante, Gouin, Pomares, Vitaro, Tremblay and Booij. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Linda Booij, CHU Sainte-Justine Research Center, Université de Montréal, Montréal, Canada, linda.booij@queensu.ca