%A Sisakhti,Minoo %A Sachdev,Perminder S. %A Batouli,Seyed Amir Hossein %D 2021 %J Frontiers in Human Neuroscience %C %F %G English %K long term memory,visual memory,Cognitive Load,memory retrieval,functional MRI (fMRI) %Q %R 10.3389/fnhum.2021.700146 %W %L %M %P %7 %8 2021-October-13 %9 Original Research %# %! long-term memory retrieval load %* %< %T The Effect of Cognitive Load on the Retrieval of Long-Term Memory: An fMRI Study %U https://www.frontiersin.org/articles/10.3389/fnhum.2021.700146 %V 15 %0 JOURNAL ARTICLE %@ 1662-5161 %X One of the less well-understood aspects of memory function is the mechanism by which the brain responds to an increasing load of memory, either during encoding or retrieval. Identifying the brain structures which manage this increasing cognitive demand would enhance our knowledge of human memory. Despite numerous studies about the effect of cognitive loads on working memory processes, whether these can be applied to long-term memory processes is unclear. We asked 32 healthy young volunteers to memorize all possible details of 24 images over a 12-day period ending 2 days before the fMRI scan. The images were of 12 categories relevant to daily events, with each category including a high and a low load image. Behavioral assessments on a separate group of participants (#22) provided the average loads of the images. The participants had to retrieve these previously memorized images during the fMRI scan in 15 s, with their eyes closed. We observed seven brain structures showing the highest activation with increasing load of the retrieved images, viz. parahippocampus, cerebellum, superior lateral occipital, fusiform and lingual gyri, precuneus, and posterior cingulate gyrus. Some structures showed reduced activation when retrieving higher load images, such as the anterior cingulate, insula, and supramarginal and postcentral gyri. The findings of this study revealed that the mechanism by which a difficult-to-retrieve memory is handled is mainly by elevating the activation of the responsible brain areas and not by getting other brain regions involved, which is a help to better understand the LTM retrieval process in the human brain.