AUTHOR=Ziegler Gabriel , Dahnke Robert , Gaser Christian 

TITLE=Models of the aging brain structure and individual decline

JOURNAL=Frontiers in Neuroinformatics

VOLUME=6

YEAR=2012

URL=https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2012.00003

DOI=10.3389/fninf.2012.00003

ISSN=1662-5196

ABSTRACT=<p>The aging brain’s structural development constitutes a spatiotemporal process that is accessible by MR-based computational morphometry. Here we introduce basic concepts and analytical approaches to quantify age-related differences and changes in neuroanatomical images of the human brain. The presented models first address the estimation of age trajectories, then we consider inter-individual variations of structural decline, using a repeated measures design. We concentrate our overview on preprocessed neuroanatomical images of the human brain to facilitate practical applications to diverse voxel- and surface-based structural markers. Together these methods afford analysis of aging brain structure in relation to behavioral, health, or cognitive parameters.</p>