AUTHOR=Steiner Adam P., Redish A. David TITLE=The Road Not Taken: Neural Correlates of Decision Making in Orbitofrontal Cortex JOURNAL=Frontiers in Neuroscience VOLUME=6 YEAR=2012 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2012.00131 DOI=10.3389/fnins.2012.00131 ISSN=1662-453X ABSTRACT=

Empirical research links human orbitofrontal cortex (OFC) to the evaluation of outcomes during decision making and the representation of alternative (better) outcomes after failures. When faced with a difficult decision, rats sometimes pause and turn back-and-forth toward goals, until finally orienting toward the chosen direction. Neural representations of reward in rodent OFC increased immediately following each reorientation, implying a transient representation of the expected outcome following self-initiated decisions. Upon reaching reward locations and finding no reward (having made an error), OFC representations of reward decreased locally indicating a disappointment signal that then switched to represent the unrewarded, non-local, would-have-been rewarded site. These results illustrate that following a decision to act, neural ensembles in OFC represent reward, and upon the realization of an error, represent the reward that could have been.