AUTHOR=van de Lagemaat Louie N. , Nijhof Bonnie , Bosch Daniëlle G. M. , Kohansal-Nodehi Mahdokht , Keerthikumar Shivakumar , Heimel J. Alexander TITLE=Age-related decreased inhibitory vs. excitatory gene expression in the adult autistic brain JOURNAL=Frontiers in Neuroscience VOLUME=8 YEAR=2014 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2014.00394 DOI=10.3389/fnins.2014.00394 ISSN=1662-453X ABSTRACT=

Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by impaired social interaction and communication, and restricted behavior and interests. A disruption in the balance of excitatory and inhibitory neurotransmission has been hypothesized to underlie these disorders. Here we demonstrate that genes of both pathways are affected by ASD, and that gene expression of inhibitory and excitatory genes is altered in the cerebral cortex of adult but not younger autistic individuals. We have developed a measure for the difference in the level of excitation and inhibition based on gene expression and observe that in this measure inhibition is decreased relative to excitation in adult ASD compared to control. This difference was undetectable in young autistic brains. Given that many psychiatric features of autism are already present at an early age, this suggests that the observed imbalance in gene expression is an aging phenomenon in ASD rather than its underlying cause.