AUTHOR=Johnson Aaron W. , Hissen Sarah L. , Macefield Vaughan G. , Brown Rachael , Taylor Chloe E. 

TITLE=Magnitude of Morning Surge in Blood Pressure Is Associated with Sympathetic but Not Cardiac Baroreflex Sensitivity

JOURNAL=Frontiers in Neuroscience

VOLUME=10

YEAR=2016

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2016.00412

DOI=10.3389/fnins.2016.00412

ISSN=1662-453X

ABSTRACT=<p>The ability of the arterial baroreflex to regulate blood pressure may influence the magnitude of the morning surge in blood pressure (MSBP). The aim was to investigate the relationships between sympathetic and cardiac baroreflex sensitivity (BRS) and the morning surge. Twenty-four hour ambulatory blood pressure was recorded in 14 young individuals. The morning surge was defined via the pre-awakening method, which is calculated as the difference between mean blood pressure values 2 h before and 2 h after rising from sleep. The mean systolic morning surge, diastolic morning surge, and morning surge in mean arterial pressures were 15 ± 2, 13 ± 1, and 11 ± 1 mmHg, respectively. During the laboratory protocol, continuous measurements of blood pressure, heart rate, and muscle sympathetic nerve activity (MSNA) were made over a 10-min period of rest. Sympathetic BRS was quantified by plotting MSNA burst incidence against diastolic pressure (sympathetic BRS<sub>inc</sub>), and by plotting total MSNA against diastolic pressure (sympathetic BRS<sub>total</sub>). Cardiac BRS was quantified using the sequence method. The mean values for sympathetic BRS<sub>inc</sub>, sympathetic BRS<sub>total</sub> and cardiac BRS were −1.26 ± 0.26 bursts/100 hb/mmHg, −1.60 ± 0.37 AU/beat/mmHg, and 13.1 ± 1.5 ms/mmHg respectively. Significant relationships were identified between sympathetic BRS<sub>inc</sub> and the diastolic morning surge (<italic>r</italic> = 0.62, <italic>p</italic> = 0.02) and the morning surge in mean arterial pressure (<italic>r</italic> = 0.57, <italic>p</italic> = 0.03). Low sympathetic BRS was associated with a larger morning surge in mean arterial and diastolic blood pressure. Trends for relationships were identified between sympathetic BRS<sub>total</sub> and the diastolic morning surge (<italic>r</italic> = 0.52, <italic>p</italic> = 0.066) and the morning surge in mean arterial pressure (<italic>r</italic> = 0.48, <italic>p</italic> = 0.095) but these did not reach significance. There were no significant relationships between cardiac BRS and the morning surge. These findings indicate that the ability of the baroreflex to buffer increases in blood pressure via reflexive changes in MSNA may play a role in determining the magnitude of the MSBP.</p>