AUTHOR=Avila Jesús , Llorens-Martín María , Pallas-Bazarra Noemí , Bolós Marta , Perea Juan R. , Rodríguez-Matellán Alberto , Hernández Félix 

TITLE=Cognitive Decline in Neuronal Aging and Alzheimer's Disease: Role of NMDA Receptors and Associated Proteins

JOURNAL=Frontiers in Neuroscience

VOLUME=11

YEAR=2017

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2017.00626

DOI=10.3389/fnins.2017.00626

ISSN=1662-453X

ABSTRACT=<p>Molecular changes associated with neuronal aging lead to a decrease in cognitive capacity. Here we discuss these alterations at the level of brain regions, brain cells, and brain membrane and cytoskeletal proteins with an special focus in NMDA molecular changes through aging and its effect in cognitive decline and Alzheimer disease. Here, we propose that some neurodegenerative disorders, like Alzheimer's disease (AD), are characterized by an increase and acceleration of some of these changes.</p>