@ARTICLE{10.3389/fnins.2018.00176, AUTHOR={Bieck, Silke M. and Artemenko, Christina and Moeller, Korbinian and Klein, Elise}, TITLE={Low to No Effect: Application of tRNS During Two-Digit Addition}, JOURNAL={Frontiers in Neuroscience}, VOLUME={12}, YEAR={2018}, URL={https://www.frontiersin.org/articles/10.3389/fnins.2018.00176}, DOI={10.3389/fnins.2018.00176}, ISSN={1662-453X}, ABSTRACT={Transcranial electric stimulation such as transcranial random noise stimulation (tRNS) and transcranial direct current stimulation (tDCS) have been used to investigate structure-function relationships in numerical cognition. Recently, tRNS was suggested to be more effective than tDCS. However, so far there is no evidence on the differential impact of tDCS and tRNS on numerical cognition using the same experimental paradigm. In the present study, we used a two-digit addition paradigm for which significant—albeit small—effects of tDCS were observed previously to evaluate the impact of parietal and frontal tRNS on specific numerical effects. While previous studies reported a modulation of numerical effects of this task through tDCS applied to parietal areas, we did not observe any effect of parietal tRNS on performance in two-digit addition. These findings suggest that tRNS seemed to influence concurrent mental arithmetic less than tDCS at least when applied over the IPS. These generally small to absent effects of tES on actual arithmetic performance in the current addition paradigm are in line with the results of a recent meta-analysis indicating that influences of tES may be more pronounced in training paradigms.} }