AUTHOR=Steinfurth Elisa C. K. , Wendt Julia , Geisler Fay , Hamm Alfons O. , Thayer Julian F. , Koenig Julian 

TITLE=Resting State Vagally-Mediated Heart Rate Variability Is Associated With Neural Activity During Explicit Emotion Regulation

JOURNAL=Frontiers in Neuroscience

VOLUME=12

YEAR=2018

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2018.00794

DOI=10.3389/fnins.2018.00794

ISSN=1662-453X

ABSTRACT=<p>Resting state vagally mediated heart rate variability (vmHRV) is related to difficulties in emotion regulation (ER). The prefrontal cortex (PFC) provides inhibitory control over the amygdala during ER. Previous studies linked vmHRV with activity in the ventromedial PFC (vmPFC) during <italic>implicit</italic> ER. To date no study examined the relation between vmHRV and brain activity during <italic>explicit</italic> ER. vmHRV was measured during a 7 min baseline at T1 2–5 days preceding T2. At T2 <italic>n</italic> = 24 participants (50% female, <italic>M</italic><sub>age</sub> = 24.6 years) viewed neutral or emotional pictures of pleasant or unpleasant valence and were instructed to intensify or to reduce their present emotion using two ER strategies (<italic>reappraisal</italic> and <italic>response</italic><italic>modulation</italic>) or to passively view the picture. Participants rated the valence of their emotional state from pleasant to unpleasant after ER. Whole-brain fMRI data were collected using a 1.5-T-scanner. We observed an association between resting state vmHRV and brain activation in the PFC and the amygdala during ER of unpleasant emotions. Groups based on vmHRV showed significant differences in the modulation of amygdala activity as a function of ER strategy. In participants with <italic>high</italic> vmHRV amygdala activity was modulated only when using <italic>reappraisal</italic> and for <italic>low</italic> vmHRV participants only when using <italic>response modulation</italic>. Similar, dorsomedial PFC activity in <italic>high</italic> vmHRV participants was increased when using <italic>reappraisal</italic> and in <italic>low</italic> vmHRV participants when using <italic>response modulation</italic> to regulate unpleasant emotions. These results suggest that individuals with <italic>low</italic> vmHRV might have difficulties in recruiting prefrontal brain areas necessary for the modulation of amygdala activity during explicit ER.</p>