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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurosci. | doi: 10.3389/fnins.2019.01149

Progress of research on exosomes in the protection against ischemic brain injury

  • 1Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, China
  • 2Wenzhou Medical University, China
  • 3Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, China

Exosomes, as a type of extracellular vesicle (EV), are lipid bilayer vesicles 20-100 nm in diameter that can cross the blood-brain barrier. Exosomes are important transport vesicles in the human body that participate in many conduction pathways and play an important physiological role. Because of their high biocompatibility and low immunogenicity and toxicity, exosomes have attracted increasing attention as an attractive drug delivery system. This article reviews the relevant studies that have shown that exosomes play an important role in protective mechanisms against ischemic brain injury.

Keywords: exosome, brain protection, Ischemic brain injury, Stroke, Drug delivery

Received: 23 Jul 2019; Accepted: 11 Oct 2019.

Copyright: © 2019 Kang, Zuo, Hong, Tang and Geng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Wujun Geng, Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China, gengwujun@wzhospital.cn