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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Neurosci.</journal-id>
<journal-title>Frontiers in Neuroscience</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Neurosci.</abbrev-journal-title>
<issn pub-type="epub">1662-453X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fnins.2021.696830</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Neuroscience</subject>
<subj-group>
<subject>General Commentary</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Commentary: Management of Intractable Pain in Patients With Implanted Spinal Cord Stimulation Devices During the COVID-19 Pandemic Using a Remote and Wireless Programming System</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Dario</surname> <given-names>Alessandro</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x0002A;</sup></xref>
<xref ref-type="author-notes" rid="fn002"><sup>&#x02020;</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1271107/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Frigerio</surname> <given-names>Giovanni</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="author-notes" rid="fn002"><sup>&#x02020;</sup></xref>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>Department of Neurosurgery, ASST Settelaghi, Insubria University</institution>, <addr-line>Varese</addr-line>, <country>Italy</country></aff>
<aff id="aff2"><sup>2</sup><institution>Pain Unit, Istituto Villa Aprica</institution>, <addr-line>Como</addr-line>, <country>Italy</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Waldemar Karwowski, University of Central Florida, United States</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Marc Russo, Genesis Research Services, Australia</p></fn>
<corresp id="c001">&#x0002A;Correspondence: Alessandro Dario <email>dario.alessandro&#x00040;virgilio.it</email></corresp>
<fn fn-type="other" id="fn001"><p>This article was submitted to Neural Technology, a section of the journal Frontiers in Neuroscience</p></fn>
<fn fn-type="other" id="fn002"><p>&#x02020;These authors have contributed equally to this work and share first authorship</p></fn></author-notes>
<pub-date pub-type="epub">
<day>05</day>
<month>08</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="collection">
<year>2021</year>
</pub-date>
<volume>15</volume>
<elocation-id>696830</elocation-id>
<history>
<date date-type="received">
<day>17</day>
<month>04</month>
<year>2021</year>
</date>
<date date-type="accepted">
<day>05</day>
<month>07</month>
<year>2021</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2021 Dario and Frigerio.</copyright-statement>
<copyright-year>2021</copyright-year>
<copyright-holder>Dario and Frigerio</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license> </permissions>
<related-article id="RA1" related-article-type="commentary-article" journal-id="Front. Neurosci." journal-id-type="nlm-ta" vol="14" page="594696" xlink:href="33363453" ext-link-type="pubmed">A Commentary on <article-title>Management of Intractable Pain in Patients With Implanted Spinal Cord Stimulation Devices During the COVID-19 Pandemic Using a Remote and Wireless Programming System</article-title> by Lu, Y., Xie, D., Zhang, X., Dong, S., Zhang, H., Yu, B., et al. (2020). Front. Neurosci. 14:594696. doi: <object-id>10.3389/fnins.2020.594696</object-id></related-article>
<kwd-group>
<kwd>spinal cord stimulation</kwd>
<kwd>telemedicine</kwd>
<kwd>trial</kwd>
<kwd>COVID-19</kwd>
<kwd>reimbursement</kwd>
</kwd-group>
<counts>
<fig-count count="0"/>
<table-count count="0"/>
<equation-count count="0"/>
<ref-count count="18"/>
<page-count count="3"/>
<word-count count="2123"/>
</counts>
</article-meta>
</front>
<body>
<p>The article by Lu et al. (<xref ref-type="bibr" rid="B16">2020</xref>) regarding the use of a remote and wireless programming system with a spinal cord stimulation (SCS) device during the COVID-19 pandemic is very interesting since it focuses on the use of telemedicine with SCS in this particular period and, hence, opens up new scenarios in the field of neurostimulation.</p>
<p>We believe that the main points on the SCS management given by the pandemic are mainly two: first is the extensive use of telemedicine after having solved the regulatory problems and the education of the patients; and second is the possibility to perform with the one-shot implant.</p>
<p>In particular, before the pandemic, the use of telemedicine was quite limited in neurosurgical practice (Basil et al., <xref ref-type="bibr" rid="B2">2021</xref>).</p>
<p>On the other hand, two neurostimulator implants are required for a successful application: the trial implant and the definitive implant. This temporal procedure may be limited by the current demands that the health system faces to combat the pandemic.</p>
<p>In two experienced SCS centers in Lombardy, due to the restrictions of social contact during the epidemic, the follow-up in the trial period between the SCS programmer doctor and the patient was largely by telephone or video system. However, the novelty of the new system, the inability to use it by elderly people, and the difficulty of communication caused relationship problems between the doctor and the patient. Hence, out of 31 patients with SCS trials, 5 patients could not get an indication from the trial because it was not actually performed in their case (Dario et al., <xref ref-type="bibr" rid="B6">2021</xref>).</p>
<sec id="s1">
<title>Telehealth and Scs</title>
<p>The use of telemedicine in SCS implantation-indication as reported is rather low (Basil et al., <xref ref-type="bibr" rid="B2">2021</xref>), but it is during the trial or immediately after the definitive implantation that telemedicine can almost completely replace face to face visits (Lu et al., <xref ref-type="bibr" rid="B16">2020</xref>). This method can be an innovation in the management of SCS for chronic pain and it must be used to offer the best experience for patients with chronic pain (Marinangeli et al., <xref ref-type="bibr" rid="B17">2020</xref>).</p>
<p>Worldwide, the use of telemedicine systems is still lagging (Golinelli et al., <xref ref-type="bibr" rid="B14">2020</xref>). In Italy, the &#x0201C;Telemedicine National Guidelines&#x0201D; recognizes the substantial equivalence between the services provided in telemedicine and traditional service. The integration of traditional services and telemedicine should be framed organically within diagnostic-therapeutic-assistance paths (Ferorelli et al., <xref ref-type="bibr" rid="B12">2020</xref>). Moreover, the report provided by the National Health Institute in April 2020 entitled &#x0201C;Interim indications for telemedicine assistance services during the COVID-19 health emergency&#x0201D; proposed the implementation of telemedicine in subjects suffering from chronic disease or in frail conditions: the chronic pain can be considered a chronic disease that necessitates continuous health monitoring since spontaneous recovery is rare (Eccleston et al., <xref ref-type="bibr" rid="B9">2020</xref>).</p>
<p>Unfortunately, the speed of pandemic expansion in Italy did not allow for the adequate development of telemedicine services in relation to the SCS and, above all, the adequate integration of the regulatory framework throughout the national territory. On the other hand, Italian telemedicine services concerning cardiology, pulmonology, and neurology are already being implemented before the pandemic (Cilia et al., <xref ref-type="bibr" rid="B5">2020</xref>; De Simone et al., <xref ref-type="bibr" rid="B7">2020</xref>). As a first step in telemedicine, a telephone call with answers to simple and clear questions about the course of pain in patients with SCS may be appropriate (Emerick et al., <xref ref-type="bibr" rid="B11">2020</xref>).</p>
</sec>
<sec id="s2">
<title>Trial or No Trial</title>
<p>Recently, the need for a trial prior to implantation of the definitive neurostimulator has been questioned (Chadwick et al., <xref ref-type="bibr" rid="B4">2020</xref>) since the outcomes on the efficacy with respect to the distance of SCS are similar both in patients using the trial and in those who are not using it. Moreover, considerable savings could be demonstrated by the use of an implantation only without a screening trial (Eldabe et al., <xref ref-type="bibr" rid="B10">2020</xref>). Furthermore, the adoption of neurostimulators capable of using multiple waveforms has increased the positive results (Haider et al., <xref ref-type="bibr" rid="B15">2018</xref>; Fishman et al., <xref ref-type="bibr" rid="B13">2020</xref>) and the use of devices with an external IPG has eliminated the need for an implantable battery (Ahmadi et al., <xref ref-type="bibr" rid="B1">2021</xref>).</p>
</sec>
<sec sec-type="discussion" id="s3">
<title>Discussion</title>
<p>At the moment, telemedicine is a necessity during the pandemic. However, it could also be an improvement for the future management of SCS. Our experience was not completely positive, but this was due to the fact that, in a short time, we had to adapt to the emergency of the pandemic with a relatively low number of implants. Moreover, telemedicine provides for an experience both by the doctor and the patient or their family members. SCS telemedicine requires the patient or family members to know how to use web links. This may be the most critical point of the whole procedure; failure to connect via the web can increase the sense of abandonment of the patient as experienced by some of our patients, who then rejected the definitive implant. In many countries, older patients could need the presence of a family member or a caregiver to use the internet. The satisfaction with teleconsultations is reported to be high and 45% of doctors plan to continue telemedicine after the epidemic has waned (Tandon et al., <xref ref-type="bibr" rid="B18">2021</xref>).</p>
<p>However, the problem on how to obtain the appropriate reimbursement for visits that are made online remains. Moreover, there is a need for legislation and medicolegal value focused on SCS telemedicine (Blue et al., <xref ref-type="bibr" rid="B3">2020</xref>).</p>
<p>SCS telemedicine is an opportunity that can be enhanced by the use of devices that offer different neurostimulation waves or that can be implanted with a single intervention. In fact, new waveforms and multiple programs help because they offer more programs to test and, therefore, get the most suitable positive result for the patient (Haider et al., <xref ref-type="bibr" rid="B15">2018</xref>).</p>
<p>We congratulate Doctor Lu and colleagues for demonstrating the advances in SCS telemedicine, and we hope that this method will be applicable to all spinal neurostimulation devices.</p>
<p>Moreover, the possibility of implanting the whole system in a hospital intervention in a single day is another encouraging factor in the health system, which is currently overwhelmed by the COVID-19 pandemic. However, the one-shot implant should be reserved for those patients who meet the appropriateness criteria for SCS (Deer et al., <xref ref-type="bibr" rid="B8">2014</xref>).</p>
<p>In conclusion, the impact of COVID-19 on SCS procedures may have been negative but the pandemic has offered opportunities to change the clinical and economic management of the implants themselves and has alternative options for progress in the use of this technique. Two seem to be the key points of this progress: the use of telemedicine and the one-shot SCS implant.</p>
</sec>
<sec id="s4">
<title>Author Contributions</title>
<p>AD and GF designed and conceptualized this work and participated in drafting the manuscript. Both authors contributed to the article and approved the submitted version.</p>
</sec>
<sec sec-type="COI-statement" id="conf1">
<title>Conflict of Interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="s5">
<title>Publisher&#x00027;s Note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec> </body>
<back>

<ref-list>
<title>References</title>
<ref id="B1">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ahmadi</surname> <given-names>R.</given-names></name> <name><surname>Campos</surname> <given-names>B.</given-names></name> <name><surname>Hajiabadi</surname> <given-names>M. M.</given-names></name> <name><surname>Doerr-Harim</surname> <given-names>C.</given-names></name> <name><surname>Tenckohoff</surname> <given-names>S.</given-names></name> <name><surname>Rasche</surname> <given-names>D.</given-names></name> <etal/></person-group>. (<year>2021</year>). <article-title>Efficacy of different spinal cord stimulation paradigms for the treatment of chronic neuropathic pain (PARS-trial): study protocol for a double-blinded, randomized, and placebo-controlled crossover trial</article-title>. <source>Trials</source> <volume>22</volume>:<fpage>87</fpage>. <pub-id pub-id-type="doi">10.1186/s13063-020-05013-7</pub-id><pub-id pub-id-type="pmid">33494781</pub-id></citation></ref>
<ref id="B2">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Basil</surname> <given-names>G. W.</given-names></name> <name><surname>Eichberg</surname> <given-names>D. G.</given-names></name> <name><surname>Perz-Dickens</surname> <given-names>M.</given-names></name> <name><surname>Menendez</surname> <given-names>I.</given-names></name> <name><surname>Ivan</surname> <given-names>M. E.</given-names></name> <name><surname>Urakov</surname> <given-names>T.</given-names></name> <etal/></person-group>. (<year>2021</year>). <article-title>Differences between neurosurgical subspecialties in telehealth adoption</article-title>. <source>World Neurosurg.</source>, <volume>146</volume>, <fpage>e323</fpage>&#x02013;<lpage>e327</lpage>. <pub-id pub-id-type="doi">10.1016/j.wneu.2020.10.080</pub-id><pub-id pub-id-type="pmid">33212275</pub-id></citation></ref>
<ref id="B3">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Blue</surname> <given-names>R.</given-names></name> <name><surname>Yang</surname> <given-names>A. I.</given-names></name> <name><surname>Zhou</surname> <given-names>C.</given-names></name> <name><surname>De Ravin</surname> <given-names>E.</given-names></name> <name><surname>Teng</surname> <given-names>C. W.</given-names></name> <name><surname>Arguelles</surname> <given-names>G. R.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>Telemedicine in the era of coronavirus disease 2019 (COVID-19): a neurosurgical perspective</article-title>. <source>World Neurosurg.</source> <volume>139</volume>, <fpage>549</fpage>&#x02013;<lpage>557</lpage>. <pub-id pub-id-type="doi">10.1016/j.wneu.2020.05.066</pub-id><pub-id pub-id-type="pmid">32426065</pub-id></citation></ref>
<ref id="B4">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Chadwick</surname> <given-names>R.</given-names></name> <name><surname>McNaughton</surname> <given-names>R.</given-names></name> <name><surname>Eldabe</surname> <given-names>S.</given-names></name> <name><surname>Baranidharan</surname> <given-names>G.</given-names></name> <name><surname>Bell</surname> <given-names>J.</given-names></name> <name><surname>Brookes</surname> <given-names>M.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>To trial or not to trial before spinal cord stimulation for chronic neuropathic pain: the patients&#x00027; view from the TRIAL-STIM randomized controlled trial</article-title>. <source>Neuromodulation</source> <volume>24</volume>, <fpage>459</fpage>&#x02013;<lpage>470</lpage>. <pub-id pub-id-type="doi">10.1111/ner.13316</pub-id><pub-id pub-id-type="pmid">33258531</pub-id></citation></ref>
<ref id="B5">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cilia</surname> <given-names>R.</given-names></name> <name><surname>Mancini</surname> <given-names>F.</given-names></name> <name><surname>Bloem</surname> <given-names>B. R.</given-names></name> <name><surname>Eleopra</surname> <given-names>R.</given-names></name></person-group> (<year>2020</year>). <article-title>Telemedicine for parkinsonism: a two-step model based on the COVID-19 experience in Milan, Italy</article-title>. <source>Parkinsonism Relat. Disord.</source> <volume>75</volume>, <fpage>130</fpage>&#x02013;<lpage>132</lpage>. <pub-id pub-id-type="doi">10.1016/j.parkreldis.2020.05.038</pub-id><pub-id pub-id-type="pmid">32723588</pub-id></citation></ref>
<ref id="B6">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Dario</surname> <given-names>A.</given-names></name> <name><surname>Innamorato</surname> <given-names>M.</given-names></name> <name><surname>Frigerio</surname> <given-names>G.</given-names></name></person-group> (<year>2021</year>). <article-title>Spinal cord stimulation and COVID-19 pandemic: an Italian experience</article-title>. <source>Minerva Anestesiol.</source> <pub-id pub-id-type="doi">10.23736/S0375-9393.21.15701-3</pub-id>. <pub-id pub-id-type="pmid">33853278</pub-id> [Epub ahead of print].</citation></ref>
<ref id="B7">
<citation citation-type="web"><person-group person-group-type="author"><name><surname>De Simone</surname> <given-names>V.</given-names></name> <name><surname>Guarise</surname> <given-names>P.</given-names></name> <name><surname>Guardalben</surname> <given-names>S.</given-names></name> <name><surname>Padovani N,Tondelli</surname> <given-names>S.</given-names></name> <name><surname>Sandrini</surname> <given-names>D.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>Telecardiology during the Covid-19 pandemic: past mistakes and future hopes</article-title>. <source>Am. J. Cardiovasc. Dis.</source> <volume>10</volume>, <fpage>34</fpage>&#x02013;<lpage>47</lpage>. Available online at: <ext-link ext-link-type="uri" xlink:href="http://www.AJCD.us/ISSN:2160-200X/AJCD0115710">www.AJCD.us/ISSN:2160-200X/AJCD0115710</ext-link><pub-id pub-id-type="pmid">32685262</pub-id></citation></ref>
<ref id="B8">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Deer</surname> <given-names>T. R.</given-names></name> <name><surname>Mekhail</surname> <given-names>N.</given-names></name> <name><surname>Provenzano</surname> <given-names>D.</given-names></name> <name><surname>Pope J Krames</surname> <given-names>E.</given-names></name> <name><surname>Leong</surname> <given-names>M.</given-names></name> <etal/></person-group>. (<year>2014</year>). <article-title>The appropriate use of neurostimulation of the spinal cord and peripheral nervous system for the treatment of chronic pain and ischemic diseases: the Neuromodulation Appropriateness Consensus Committee</article-title>. <source>Neuromodulation</source> <volume>17</volume>, <fpage>515</fpage>&#x02013;<lpage>550</lpage>. <pub-id pub-id-type="doi">10.1111/ner.12208</pub-id><pub-id pub-id-type="pmid">25112889</pub-id></citation></ref>
<ref id="B9">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Eccleston</surname> <given-names>C.</given-names></name> <name><surname>Blyth</surname> <given-names>F. M</given-names></name> <name><surname>Dear</surname> <given-names>BF</given-names></name> <name><surname>Fisher</surname> <given-names>E. A.</given-names></name> <name><surname>Keefe</surname> <given-names>F. J.</given-names></name> <name><surname>Lynch</surname> <given-names>M. E.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>Managing patients with chronic pain during the COVID-19 outbreak: considerations for the rapid introduction of remotely supported (eHealth) pain management services</article-title>. <source>Pain</source> <volume>161</volume>, <fpage>889</fpage>&#x02013;<lpage>893</lpage>. <pub-id pub-id-type="doi">10.1097/j.pain.0000000000001885</pub-id><pub-id pub-id-type="pmid">32251203</pub-id></citation></ref>
<ref id="B10">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Eldabe</surname> <given-names>S.</given-names></name> <name><surname>Duarte</surname> <given-names>R. V.</given-names></name> <name><surname>Gulve</surname> <given-names>A.</given-names></name> <name><surname>Thomson S,Baranidharan</surname> <given-names>G.</given-names></name> <name><surname>Houten</surname> <given-names>R.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>Does a screening trial for spinal cord stimulation in patients with chronic pain of neuropathic origin have clinical utility and cost-effectiveness (TRIAL-STIM)? A randomised controlled trial</article-title>. <source>Pain</source> <volume>161</volume>, <fpage>2820</fpage>&#x02013;<lpage>2829</lpage>. <pub-id pub-id-type="doi">10.1097/j.pain.0000000000001977</pub-id><pub-id pub-id-type="pmid">32618875</pub-id></citation></ref>
<ref id="B11">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Emerick</surname> <given-names>T.</given-names></name> <name><surname>Alter</surname> <given-names>B.</given-names></name> <name><surname>Jarquin</surname> <given-names>S.</given-names></name> <name><surname>Brancolini</surname> <given-names>S.</given-names></name> <name><surname>Bernstein</surname> <given-names>C.</given-names></name> <name><surname>Luong</surname> <given-names>K.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>Telemedicine for chronic pain in the COVID-19 era and beyond</article-title>. <source>Pain Med.</source> <volume>21</volume>, <fpage>1743</fpage>&#x02013;<lpage>1748</lpage>. <pub-id pub-id-type="doi">10.1093/pm/pnaa220</pub-id><pub-id pub-id-type="pmid">33899110</pub-id></citation></ref>
<ref id="B12">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ferorelli</surname> <given-names>D.</given-names></name> <name><surname>Mandarelli</surname> <given-names>G.</given-names></name> <name><surname>Solarino</surname> <given-names>B.</given-names></name></person-group> (<year>2020</year>). <article-title>Ethical challenges in health care policy during COVID-19 pandemic in Italy.</article-title> <source>Medicine</source> <volume>56</volume>:<fpage>691</fpage>. <pub-id pub-id-type="doi">10.3390/medicina56120691</pub-id><pub-id pub-id-type="pmid">33322462</pub-id></citation></ref>
<ref id="B13">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Fishman</surname> <given-names>M. A.</given-names></name> <name><surname>Calodney</surname> <given-names>A.</given-names></name> <name><surname>Kim</surname> <given-names>P.</given-names></name> <name><surname>Slezak</surname> <given-names>J.</given-names></name> <name><surname>Benyamin</surname> <given-names>R.</given-names></name> <name><surname>Rehman</surname> <given-names>A.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>Prospective, multicenter feasibility study to evaluate differential target multiplexed spinal cord stimulation programming in subjects with chronic intractable back pain with or without leg pain</article-title>. <source>Pain Pract</source>. <volume>20</volume>, <fpage>761</fpage>&#x02013;<lpage>768</lpage>. <pub-id pub-id-type="doi">10.1111/papr.12908</pub-id><pub-id pub-id-type="pmid">32462791</pub-id></citation></ref>
<ref id="B14">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Golinelli</surname> <given-names>D.</given-names></name> <name><surname>Boetto</surname> <given-names>E.</given-names></name> <name><surname>Carullo</surname> <given-names>G.</given-names></name> <name><surname>Nuzzolese</surname> <given-names>A. G.</given-names></name> <name><surname>Landini</surname> <given-names>M. P.</given-names></name> <name><surname>Fantini</surname> <given-names>M. P.</given-names></name></person-group> (<year>2020</year>). <article-title>Adoption of digital technologies in health care during the COVID-19 pandemic: systematic review of early scientific literature</article-title>. <source>J. Med. Internet. Res</source>. <volume>22</volume>:<fpage>e22280</fpage>. <pub-id pub-id-type="doi">10.2196/22280</pub-id><pub-id pub-id-type="pmid">33079693</pub-id></citation></ref>
<ref id="B15">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Haider</surname> <given-names>N.</given-names></name> <name><surname>Ligham</surname> <given-names>D.</given-names></name> <name><surname>Quave</surname> <given-names>B.</given-names></name> <name><surname>Harum</surname> <given-names>K. E.</given-names></name> <name><surname>Garcia</surname> <given-names>E. A.</given-names></name> <name><surname>Gilmore</surname> <given-names>C. A.</given-names></name> <etal/></person-group>. (<year>2018</year>). <article-title>Spinal Cord Stimulation (SCS) trial outcomes after conversion to a multiple waveform scs system</article-title>. <source>Neuromodulation</source> <volume>21</volume>, <fpage>504</fpage>&#x02013;<lpage>507</lpage>. <pub-id pub-id-type="doi">10.1111/ner.12783</pub-id><pub-id pub-id-type="pmid">29889356</pub-id></citation></ref>
<ref id="B16">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Lu</surname> <given-names>Y.</given-names></name> <name><surname>Xie</surname> <given-names>D.</given-names></name> <name><surname>Zhang</surname> <given-names>X.</given-names></name> <name><surname>Dong</surname> <given-names>S.</given-names></name> <name><surname>Zhang</surname> <given-names>H.</given-names></name> <name><surname>Yu</surname> <given-names>B.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>Management of intractable pain in patients with implanted spinal cord stimulation devices during the COVID-19 pandemic using a remote and wireless programming system</article-title>. <source>Front. Neurosci.</source> <volume>14</volume>:<fpage>594696</fpage>. <pub-id pub-id-type="doi">10.3389/fnins.2020.594696</pub-id><pub-id pub-id-type="pmid">33363453</pub-id></citation></ref>
<ref id="B17">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Marinangeli</surname> <given-names>F.</given-names></name> <name><surname>Giarratano</surname> <given-names>A.</given-names></name> <name><surname>Petrini</surname> <given-names>F.</given-names></name></person-group> (<year>2020</year>). <article-title>Managing chronic pain patients at the time of COVID-19 pandemic</article-title>. <source>Minerva Anestesiol.</source> <volume>86</volume>, <fpage>797</fpage>&#x02013;<lpage>799</lpage>. <pub-id pub-id-type="doi">10.23736/S0375-9393.20.14666-2</pub-id><pub-id pub-id-type="pmid">32400999</pub-id></citation></ref>
<ref id="B18">
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Tandon</surname> <given-names>V.</given-names></name> <name><surname>Raheja</surname> <given-names>A.</given-names></name> <name><surname>Mishra</surname> <given-names>S.</given-names></name> <name><surname>Garg</surname> <given-names>K.</given-names></name> <name><surname>Dash</surname> <given-names>C.</given-names></name> <name><surname>Borkar</surname> <given-names>S. A.</given-names></name> <etal/></person-group>. (<year>2021</year>). <article-title>Trends in neurosurgical teleconsultation services across the globe during COVID-19 pandemic</article-title>. <source>World Neurosurg</source>. <volume>150</volume>, <fpage>e645</fpage>&#x02013;<lpage>e656</lpage>. <pub-id pub-id-type="doi">10.1016/j.wneu.2021.03.070</pub-id><pub-id pub-id-type="pmid">33757889</pub-id></citation></ref>
</ref-list>

</back>
</article>