%A Eden,Uri %A Amirnovin,Ramin %A Gale,John %A Eskandar,Emad %D 2012 %J Frontiers in Integrative Neuroscience %C %F %G English %K Deep Brain Stimulation,Generalized Linear Models,Parkinson's disease,Spike Train Modeling,Subthalamic Nucleus %Q %R 10.3389/fnint.2012.00028 %W %L %M %P %7 %8 2012-June-20 %9 Original Research %+ Prof Uri Eden,Boston University,Boston,United States,tzvi@bu.edu %# %! Characterizing the spiking dynamics of STN neurons in Parkinson's disease using GLMs %* %< %T Characterizing the spiking dynamics of subthalamic nucleus neurons in Parkinson's disease using generalized linear models %U https://www.frontiersin.org/articles/10.3389/fnint.2012.00028 %V 6 %0 JOURNAL ARTICLE %@ 1662-5145 %X Accurately describing the spiking patterns of neurons in the subthalamic nucleus (STN) of patients suffering from Parkinson's disease (PD) is important for understanding the pathogenesis of the disease and for achieving the maximum therapeutic benefit from deep brain stimulation (DBS). We analyze the spiking activity of 24 subthalamic neurons recorded in Parkinson's patients during a directed hand movement task by using a point process generalized linear model (GLM). The model relates each neuron's spiking probability simultaneously to factors associated with movement planning and execution, directional selectivity, refractoriness, bursting, and oscillatory dynamics. The model indicated that while short-term history dependence related to refractoriness and bursting are most informative in predicting spiking activity, nearly all of the neurons analyzed have a structured pattern of long-term history dependence such that the spiking probability was reduced 20–30 ms and then increased 30–60 ms after a previous spike. This suggests that the previously described oscillatory firing of neurons in the STN of Parkinson's patients during volitional movements is composed of a structured pattern of inhibition and excitation. This point process model provides a systematic framework for characterizing the dynamics of neuronal activity in STN.