AUTHOR=Pillay Siveshigan , Vizuete Jeannette , Liu Xiping , Juhasz Gabor , Hudetz Anthony G. TITLE=Brainstem stimulation augments information integration in the cerebral cortex of desflurane-anesthetized rats JOURNAL=Frontiers in Integrative Neuroscience VOLUME=8 YEAR=2014 URL=https://www.frontiersin.org/journals/integrative-neuroscience/articles/10.3389/fnint.2014.00008 DOI=10.3389/fnint.2014.00008 ISSN=1662-5145 ABSTRACT=
States of consciousness have been associated with information integration in the brain as modulated by anesthesia and the ascending arousal system. The present study was designed to test the hypothesis that electrical stimulation of the oral part of the pontine reticular nucleus (PnO) can augment information integration in the cerebral cortex of anesthetized rats. Extracellular unit activity and local field potentials were recorded in freely moving animals from parietal association (PtA) and secondary visual (V2) cortices via chronically implanted microwire arrays at three levels of anesthesia produced by desflurane: 3.5, 4.5, and 6.0% (where 4.5% corresponds to that critical for the loss of consciousness). Information integration was characterized by