AUTHOR=Ransdell Joseph L., Faust Tyler B., Schulz David J. TITLE=Correlated Levels of mRNA and Soma Size in Single Identified Neurons: Evidence for Compartment-specific Regulation of Gene Expression JOURNAL=Frontiers in Molecular Neuroscience VOLUME=3 YEAR=2010 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2010.00116 DOI=10.3389/fnmol.2010.00116 ISSN=1662-5099 ABSTRACT=
In addition to the overall complexity of transcriptional regulation, cells also must take into account the subcellular distribution of these gene products. This is particularly challenging for morphologically complex cells such as neurons. Yet the interaction between cellular morphology and gene expression is poorly understood. Here we provide some of the first evidence for a relationship between neuronal compartment size and maintenance of mRNA levels in neurons. We find that single-cell transcript levels of 18S rRNA,