AUTHOR=Venø Morten T. , Venø Susanne T. , Rehberg Kati , van Asperen Jessy V. , Clausen Bettina H. , Holm Ida E. , Pasterkamp R. Jeroen , Finsen Bente , Kjems Jørgen 

TITLE=Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=10

YEAR=2017

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2017.00031

DOI=10.3389/fnmol.2017.00031

ISSN=1662-5099

ABSTRACT=<p>The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical folding. These miRNAs were found to target Doublecortin (DCX), known to be involved in neuron migration during cortical folding of gyrencephalic brains. <italic>In vivo</italic> modulation of miRNA expression in mouse embryos confirmed that miR-34c and miR-204 can control neuronal migration and cortical morphogenesis, presumably by posttranscriptional regulation of DCX.</p>