AUTHOR=Zelentsova-Levytskyi Katya , Talmi Ziv , Abboud-Jarrous Ghada , Capucha Tal , Sapir Tamar , Burstyn-Cohen Tal TITLE=Protein S Negatively Regulates Neural Stem Cell Self-Renewal through Bmi-1 Signaling JOURNAL=Frontiers in Molecular Neuroscience VOLUME=10 YEAR=2017 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2017.00124 DOI=10.3389/fnmol.2017.00124 ISSN=1662-5099 ABSTRACT=
Revealing the molecular mechanisms underlying neural stem cell self-renewal is a major goal toward understanding adult brain homeostasis. The self-renewing potential of neural stem and progenitor cells (NSPCs) must be tightly regulated to maintain brain homeostasis. We recently reported the expression of Protein S (PROS1) in adult hippocampal NSPCs, and revealed its role in regulation of NSPC quiescence and neuronal differentiation. Here, we investigate the effect of PROS1 on NSPC self-renewal and show that genetic ablation of