%A Shimshek,Derya R. %A Bus,Thorsten %A Schupp,Bettina %A Jensen,Vidar %A Marx,Verena %A Layer,Liliana E. %A Köhr,Georg %A Sprengel,Rolf %D 2017 %J Frontiers in Molecular Neuroscience %C %F %G English %K AMPA receptors,long-term potentiation (LTP),spatial working memory (SWM),spatial reference memory (SRM),GluA1,GluA2,Gria1 knockout,Gria2 knockout %Q %R 10.3389/fnmol.2017.00214 %W %L %M %P %7 %8 2017-July-04 %9 Original Research %+ Mr Rolf Sprengel,Department of Molecular Neurobiology, Max Planck Institute for Medical Research,Heidelberg, Germany,rolf.sprengel@mpimf-heidelberg.mpg.de %+ Mr Rolf Sprengel,Research Group of the Max Planck Institute for Medical Research, Institute for Anatomy and Cell Biology, Heidelberg University,Heidelberg, Germany,rolf.sprengel@mpimf-heidelberg.mpg.de %# %! GluA1 independent LTP restoration %* %< %T Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation %U https://www.frontiersin.org/articles/10.3389/fnmol.2017.00214 %V 10 %0 JOURNAL ARTICLE %@ 1662-5099 %X Spatial working memory (SWM) and the classical, tetanus-induced long-term potentiation (LTP) at hippocampal CA3/CA1 synapses are dependent on L-α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) containing GluA1 subunits as demonstrated by knockout mice lacking GluA1. In GluA1 knockout mice LTP and SWM deficits could be partially recovered by transgenic re-installation of full-length GluA1 in principle forebrain neurons. Here we partially restored hippocampal LTP in GluA1-deficient mice by forebrain-specific depletion of the GluA2 gene, by the activation of a hypomorphic GluA2(Q) allele and by transgenic expression of PDZ-site truncated GFP-GluA1(TG). In none of these three mouse lines, the partial LTP recovery improved the SWM performance of GluA1-deficient mice suggesting a specific function of intact GluA1/2 receptors and the GluA1 intracellular carboxyl-terminus in SWM and its associated behavior.