AUTHOR=Heinrich Ronit , Hertz Rivka , Zemel Esther , Mann Irit , Brenner Liat , Massarweh Amir , Berlin Shai , Perlman Ido TITLE=ATF3 Regulates the Expression of AChE During Stress JOURNAL=Frontiers in Molecular Neuroscience VOLUME=11 YEAR=2018 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2018.00088 DOI=10.3389/fnmol.2018.00088 ISSN=1662-5099 ABSTRACT=
Acetylcholinesterase (AChE) expresses in non-cholinergic cells, but its role(s) there remain unknown. We have previously attributed a pro-apoptotic role for AChE in stressed retinal photoreceptors, though by unknown mechanism. Here, we examined its promoter only to find that it includes a binding sequence for the activating transcription factor 3 (ATF3); a prototypical mediator of apoptosis. This suggests that expression of AChE could be regulated by ATF3 in the retina. Indeed, ATF3 binds the AChE-promoter to down-regulate its expressions