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Front. Mol. Neurosci. | doi: 10.3389/fnmol.2018.00341

Inflammation: a network in the pathogenesis of status epilepticus

  • 1Jinshan Hospital, Fudan University, China
  • 2Huashan Hospital Affiliated to Fudan University, China

Status epilepticus (SE) is an abnormally prolonged or recurrent epileptic seizure that is a serious, life-threatening medical emergency. Notably, it requires prompt, aggressive treatment. SE is characterized by high mortality and morbidity. However, its pathogenesis remains unclear. Numerous studies of SE have reported widespread brain inflammation, suggesting that inflammation plays a vital role in the occurrence and development of SE. This article reviews current knowledge regarding the role of inflammation in SE.

Keywords: Status Epilepticus, Inflammation, Inflammatory signaling pathway, NF-κB, Cytokines

Received: 01 Jun 2018; Accepted: 30 Aug 2018.

Edited by:

Jaewon Ko, Daegu Gyeongbuk Institute of Science and Technology (DGIST), South Korea

Reviewed by:

Eva M. Jimenez-Mateos, Royal College of Surgeons in Ireland, Ireland
Eunji Cheong, Yonsei University, South Korea  

Copyright: © 2018 Wang and Yinghui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Chen Yinghui, Huashan Hospital Affiliated to Fudan University, Shanghai, China, yinghuichen@fudan.edu.cn