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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Mol. Neurosci. | doi: 10.3389/fnmol.2019.00008

Role of palmitoylation of postsynaptic proteins in promoting synaptic plasticity

 Lucas Matt1, 2*,  Karam Kim3,  Dhrubajyoti Chowdhury3 and Johannes W. Hell3*
  • 1University of Tubingen, Germany
  • 2Pharmakologie, Toxikologie und Klinische Pharmazie, Fachbereich Pharmazie und Biochemie, Universität Tübingen, Germany
  • 3Department of Pharmacology, University of California Davis, United States

Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics. Both palmitoylation by palmitoyl acyl transferases (PAT) and depalmitoylation by palmitoyl-protein thioesterases (PPT) is regulated in an activity-dependent, localized fashion. Recently, palmitoylation has received attention for its pivotal contribution to various forms of synaptic plasticity, the dynamic modulation of synaptic strength in response to neuronal activity. For instance, palmitoylation and depalmitoylation of the central postsynaptic scaffold protein PSD-95 is important for synaptic plasticity. Here we provide a comprehensive review of studies linking palmitoylation of postsynaptic proteins to synaptic plasticity.

Keywords: PSD-95, homeostatic plasticity, AMPAR (AMPA receptor), NMDAR (NMDA receptor), LTP (Long Term Potentiation), LTD (Long Term Depression)

Received: 30 Oct 2018; Accepted: 10 Jan 2019.

Edited by:

William N. Green, University of Chicago, United States

Reviewed by:

Takashi Hayashi, National Center of Neurology and Psychiatry (Japan), Japan
Christian G. Specht, Institut National de la Santé et de la Recherche Médicale (INSERM), France  

Copyright: © 2019 Matt, Kim, Chowdhury and Hell. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Lucas Matt, University of Tubingen, Tübingen, 72074, Baden-Württemberg, Germany, lucas.matt@uni-tuebingen.de
Prof. Johannes W. Hell, Department of Pharmacology, University of California Davis, Davis, 95616, California, United States, jwhell@ucdavis.edu