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Front. Mol. Neurosci. | doi: 10.3389/fnmol.2019.00112

No association of variants of the NPY-system with obsessive-compulsive disorder in children and adolescents

 Maximilian Franke1,  Annette Conzelmann2,  Edna Grünblatt3,  Anna M. Werling3, Helen Spieles2, Christoph Wewetzer4, Andreas Warnke1, Marcel Romanos1,  Susanne Walitza3 and  Tobias J. Renner1, 2*
  • 1Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Germany
  • 2Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Tübingen, Germany
  • 3University Hospital of Child and Adolescent Psychiatry, University of Zurich, Switzerland
  • 4Department of Child and Adolescent Psychiatry and Psychotherapy, Kliniken der Stadt Köln, Germany

Obsessive compulsive disorder (OCD) causes severe distress and is therefore counted by the WHO as one of the ten most impairing illnesses. There is evidence for a strong genetic under-pinning especially in early onset OCD. Though several genes involved in neurotransmission have been reported as candidates there is still need to identify new pathways. In this study, we focussed on genetic variants of the Neuropetide Y (NPY) system. NPY is one of the most abundant neuropeptides in the human brain with emerging evidence of capacity to modulate stress response, which is of high relevance in OCD. We focussed on tag-SNPs of NPY and its receptor gene NPY1R in a family-based approach. The sample comprised 86 patients (children and adolescents) with early onset OCD with both their biological parents. However, this first study on genetic variants of the NPY-system could not confirm association between the investi-gated SNPs and early onset OCD.

Keywords: NPY (neuropeptide Y), OCD (obsessive-compulsive disorder), Children, Anxiety, Neuropeptide

Received: 31 Jul 2018; Accepted: 17 Apr 2019.

Edited by:

Ildikó Rácz, Universitätsklinikum Bonn, Germany

Reviewed by:

Subhrangshu Guhathakurta, University of Central Florida, United States
Muddanna S. Rao, Department of Anatomy, Faculty of Medicine, Kuwait University, Kuwait  

Copyright: © 2019 Franke, Conzelmann, Grünblatt, Werling, Spieles, Wewetzer, Warnke, Romanos, Walitza and Renner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Tobias J. Renner, University of Wuerzburg, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Würzburg, 97070, Bavaria, Germany,