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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Mol. Neurosci. | doi: 10.3389/fnmol.2019.00178

PIEZO1 is selectively expressed in small diameter mouse DRG neurons distinct from neurons strongly expressing TRPV1

  • 1University of Texas Medical Branch at Galveston, United States

Using a high resolution in situ hybridization technique we have measured PIEZO1, PIEZO2 and TRPV1 transcripts in mouse dorsal root ganglion (DRG) neurons. Consistent with previous studies, PIEZO2 transcripts were highly expressed in most DRG neurons, including the largest diameter neurons implicated in mediating touch and proprioception. In contrast, PIEZO1 transcripts were selectively expressed in smaller diameter DRG neurons, which are implicated in mediating nociception. Moreover, neurons expressing PIEZO1 were distinct from those neurons that strongly expressed TRPV1, one of the channels implicated in heat-nociception. Using an in vivo functional test for the selective expression, we found that Yoda1, a PIEZO1-specific agonist, induced a mechanical hyperalgesia that displayed a significantly prolonged time course compared with that induced by capsaicin, a TRPV1-specific agonist. Taken together, our results indicate that PIEZO1 should be considered a potential candidate for the long sought channel mediating mechano-nociception.

Keywords: Piezo1 channel, Nociception, TRPV1, piezo2 channels, Pain

Received: 08 Feb 2019; Accepted: 04 Jul 2019.

Edited by:

Volker Eulenburg, Department of Anaesthesiology and Intensive Therapy, University Hospital Leipzig, Germany

Reviewed by:

Gehoon Chung, Seoul National University, South Korea
Tibor Rohacs, Rutgers New Jersey Medical School  

Copyright: © 2019 Wang, La and Hamill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Owen P. Hamill, University of Texas Medical Branch at Galveston, Galveston, United States, ohamill@utmb.edu