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ORIGINAL RESEARCH article

Front. Mol. Neurosci.
Sec. Molecular Signalling and Pathways
Volume 17 - 2024 | doi: 10.3389/fnmol.2024.1400927
This article is part of the Research Topic

Nervous Regeneration and Functional Recovery in the Central and Peripheral Nervous Systems: Diagnostic Methods, Gene/Cell therapies, and Interventions

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Iridoids Rich Fraction from Valeriana Jatamansi Jones Promotes Axonal Regeneration and Motor Functional Recovery after Spinal Cord Injury through Activation of the PI3K/Akt Signaling Pathway Provisionally Accepted

Yunyun Wang1 Jiachun Lu2 Hua Xiao1 Lijuan Ding1 Yongzhi He3 Cong Chang2 Wenchun Wang4*
  • 1College of Medicine, Southwest Jiaotong University, China
  • 2Chengdu Eighth People's Hospital (Geriatric Hospital of Chengdu Medical College),, China
  • 3North Sichuan Medical College, China
  • 4Department of Rehabilitation Medicine, Western Theater General Hospital, China

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Valeriana jatamansi Jones (VJJ), renowned for its extensive history in traditional Chinese medicine and ethnomedicine within China, is prevalently utilized to alleviate ailments such as epigastric distension and pain, gastrointestinal disturbances including food accumulation, diarrhea, and dysentery, as well as insomnia and other diseases.Moreover, the Iridoid-rich fraction derived from Valeriana jatamansi Jones (IRFV) has demonstrated efficacy in facilitating the recuperation of motor functions after spinal cord injury (SCI). This study is aimed to investigate the therapeutic effect of IRFV on SCI and its underlying mechanism. Initially, a rat model of SCI was developed to assess the impact of IRFV on axonal regeneration. Subsequently, employing the PC12 cell model of oxidative damage, the role and mechanism of IRFV in enhancing axonal regeneration were explored using the phosphoinositide-3kinase (PI3K)/protein kinase B (Akt) signaling pathway inhibitor LY294002.Ultimately, the same inhibitor was administered to SCI rats to confirm the molecular mechanism through which IRFV promotes axonal regeneration by activating the PI3K/Akt signaling pathway. The results showed that IRFV significantly enhanced motor function recovery, reduced pathological injury, and facilitated axonal regeneration in SCI rats. In vitro experiments revealed that IRFV improved PC12 cell viability, augmented axonal regeneration, and activated the PI3K/Akt signaling pathway. Notably, the inhibition of this pathway negated the therapeutic benefits of IRFV in SCI rats. In conclusion, IRFV promote promotes axonal regeneration and recovery of motor function after SCI through activation of the PI3K/Akt signaling pathway.

Keywords: Iridoid-rich fraction derived from Valeriana jatamansi Jones, spinal cord injury, axonal regeneration, PI3K/AKT signaling, Traditional Chinese Medicine

Received: 14 Mar 2024; Accepted: 16 Apr 2024.

Copyright: © 2024 Wang, Lu, Xiao, Ding, He, Chang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Wenchun Wang, Department of Rehabilitation Medicine, Western Theater General Hospital, Chengdu, China