%A Prince,Luke Y. %A Bacon,Travis J. %A Tigaret,Cezar M. %A Mellor,Jack R. %D 2016 %J Frontiers in Synaptic Neuroscience %C %F %G English %K Acetylcholine,noradrenaline,Serotonin,Dopamine,Dentate Gyrus,CA3 Region, Hippocampal,Mossy Fibers, Hippocampal,computational modeling %Q %R 10.3389/fnsyn.2016.00032 %W %L %M %P %7 %8 2016-October-17 %9 Review %+ Luke Y. Prince,Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol,Bristol, UK,l.y.prince@bristol.ac.uk %+ Dr Jack R. Mellor,Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol,Bristol, UK,jack.mellor@bristol.ac.uk %# %! Neuromodulation of the DG-CA3 microcircuit %* %< %T Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit %U https://www.frontiersin.org/articles/10.3389/fnsyn.2016.00032 %V 8 %0 JOURNAL ARTICLE %@ 1663-3563 %X The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval.