AUTHOR=Choo Vivian L. , Sievenpiper John L. TITLE=The Ecologic Validity of Fructose Feeding Trials: Supraphysiological Feeding of Fructose in Human Trials Requires Careful Consideration When Drawing Conclusions on Cardiometabolic Risk JOURNAL=Frontiers in Nutrition VOLUME=2 YEAR=2015 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2015.00012 DOI=10.3389/fnut.2015.00012 ISSN=2296-861X ABSTRACT=Background

Select trials of fructose overfeeding have been used to implicate fructose as a driver of cardiometabolic risk.

Objective

We examined temporal trends of fructose dose in human controlled feeding trials of fructose and cardiometabolic risk.

Methods

We combined studies from eight meta-analyses on fructose and cardiometabolic risk to assess the average fructose dose used in these trials. Two types of trials were identified: (1) substitution trials, in which energy from fructose was exchanged with equal energy from other carbohydrates and (2) addition trials, in which energy from fructose supplemented a diet compared to the diet alone.

Results

We included 64 substitution trials and 16 addition trials. The weighted average fructose dose in substitution trials was 101.7 g/day (95% CI: 98.4–105.1 g/day), and the weighted average fructose dose in addition trials was 187.3 g/day (95% CI: 181.4–192.9 g/day).

Conclusion

Average fructose dose in substitution and addition trials greatly exceed national levels of reported fructose intake (49 ± 1.0 g/day) (NHANES 1977–2004). Future trials using fructose doses at real world levels are needed.