AUTHOR=Riccardi Daniela Mendes dos Reis , das Neves Rodrigo Xavier , de Matos-Neto Emidio Marques , Camargo Rodolfo Gonzalez , Lima Joanna Darck Carola Correia , Radloff Katrin , Alves Michele Joana , Costa Raquel Galvão Figuerêdo , Tokeshi Flávio , Otoch José Pinhata , Maximiano Linda Ferreira , de Alcantara Paulo Sérgio Martins , Colquhoun Alison , Laviano Alessandro , Seelaender Marilia 

TITLE=Plasma Lipid Profile and Systemic Inflammation in Patients With Cancer Cachexia

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 7 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2020.00004

DOI=10.3389/fnut.2020.00004

ISSN=2296-861X

ABSTRACT=Cancer cachexia is a syndrome inducing severe and fast involuntary weight loss. It affects around 80% of patients with advanced cancer and is by itself direct cause of death. Recent studies have shown that inflammatory mediators are active players in the development of cachexia. The white adipose tissue (WAT) is a contributor to inflammation as it suffers morphological reorganization and marked lipolysis, releasing free fatty acids (FFA), which accentuate the production of pro-inflammatory cytokines through the activation of pro-inflammatory signaling pathways. The aim of this study was to characterize the plasma lipid profile of cachectic patients and to correlate its FFA composition with that of inflammatory markers; finally, we sought to establish whether the fatty acids released by adipocytes trigger and/or contribute to local and systemic inflammation in cachexia. The study selected65 patients further divided into 3 groups: control (N); weight stable cancer (WSC); and cachectic cancer (CC). The plasma FFA profile was significantly different between the groups and was positively correlated with pro-inflammatory cytokines expression in CC patients. The changes in CC plasma characterize systemic inflammation and concomitant change in FFA profile.