Effects of Ramadan and Non-ramadan Intermittent Fasting on Body Composition: A Systematic Review and Meta-Analysis

Intermittent fasting (IF) has gained popularity for body-composition improvement purposes. The aim of this systematic review and meta-analysis was to summarize the effects of Ramadan vs. non-Ramadan IF on parameters of body composition. We conducted a comprehensive search of peer-reviewed articles in three electronic databases: PubMed, Scopus, and Web of Science (published until May 2020). Studies were selected if they included samples of adults (≥18 years), had an experimental or observational design, investigated any type of IF and included body composition outcomes. Meta-analytical procedures were conducted when feasible. Sixty-six articles met the eligibility criteria. We found that non-Ramadan IF is effective for decreasing body weight (−0.341 (95% CI [−0.584, −0.098], p = 0.006), body mass index (−0.699, 95% CI [−1.05, −0.347], p < 0.001), and absolute fat mass (−0.447, 95% CI [−0.673, −0.221], p < 0.001). When contrasting pre- post-intervention data on fat-free mass between treatments and controls, group-differences were non-significant (p > 0.05). Conversely, we observed a significant increase in fat-free mass when comparing pre- to post-intervention in a within design fashion (0.306, 95% CI [0.133, 0.48], p = 0.001). Finally, despite being accompanied by dehydration, Ramadan IF is effective in decreasing body weight (−0.353; 95% CI [−0.651, −0.054], p = 0.02) and relative fat mass (−0.533; 95% CI [−1.025, −0.04], p = 0.034). Ramadan IF seems to implicate some beneficial adaptations in weight management, although non-Ramadan IF appears to be more effective in improving overall body composition.


INTRODUCTION
There are several forms of intermittent fasting (IF), all using fasting periods that extend well-beyond the duration of an overnight fast and implicating limited feeding time-windows, with or without caloric restriction (1,2). For example, in timerestricted feeding/eating (TRF), eating is limited to a certain number of hours each day (3). Alternate-day fasting (ADF) consists of alternating between feasting and fasting daysfeasting is compatible with ad libitum energy intake during 24 h and fasting implicates a caloric intake ≤ 25% of daily needs (∼ 500/600 kcal during 24 h) (4,5). Recently, a focus on intermittent energy restriction (IER) has emerged in the scientific literature as an alternative approach to continuous energy restriction (CER) for improving body composition (6). It includes periods of energy restriction alternated with periods of habitual intake or minimally restricted dietary intake, allowing wider food choices (6,7). Various forms of IER are currently being used for clinical purposes, including the "5:2 diet" and the "week-on-week-off " (7)(8)(9).
The ultimate goal of most IF regimens is to improve body composition. For this reason, they are suggested to maximize the loss of fat mass (FM), while attempting to preserve fat-free mass (FFM) (3). There is compelling evidence that IF elicits reductions in body weight and FM of ∼3-8% (4, [10][11][12][13][14] and ∼4-15%, respectively (1,4,(10)(11)(12)(13). Improvements in blood lipid profile, blood pressure and insulin sensitivity have also been consistently reported (5,14). While the majority of studies explored the effectiveness of IF on improving body composition in adults with overweight/obesity (4,5,11,(13)(14)(15), there are only occasional reports that included normoponderal individuals (10,13). Despite not being a universal finding (2,16), IF has also been shown to induce slight increases in FFM [e.g., (17)]. In this specific study, the authors used a crossover design to compare TRF with an alternative diet involving three meals per day for a period of 8 weeks, with energy intake being individualized to each participant to ensure maintenance of body weight throughout both treatments (TRF and non-TRF). Under these conditions, TRF was shown to be effective in decreasing FM and increasing FFM (by ∼1.5 kg; p = 0.06) (17). In what concerns IER, and contrary to the initial belief, it seems to be unrelated to compensatory hyperphagia on ad libitum days; thus, similarly to that seen during CER, IER is accompanied by a negative caloric balance and this results in comparable changes in body composition between both interventions after 12 months of Abbreviations: IF, intermittent fasting; Ramadan IF, Ramadan intermittent fasting; TRF, time-restricted feeding; ADF, alternate-day fasting; IER, intermittent energy restriction; CER, continuous energy restriction; BMI, body mass index; FM, fat mass; FFM, fat-free mass; ATP, adenosine triphosphate; SMD, standardized mean difference; PRISMA, preferred reporting items for systematic reviews and meta-analysis; EPHPP, effective public health practice project; CMA, comprehensive meta-analysis; CI, confidence interval. treatment (7). However, instead of being externally driven, caloric restriction during IER is purely spontaneous (18).
Apart from being used for clinical purposes, IF is also used in many religious practices. A notable example is Ramadan IF, which is the most widely-studied form of IF (19). During Ramadan, Muslims abstain from ingesting food and liquids between sunrise and sunset throughout a month-long period (20,21). Thus, food and liquid intake becomes exclusively nocturnal. Even though Muslims eat ad libitum after sunset and before dawn, caloric restriction often accompanies Ramadan IF (22). Ramadan IF can last ∼12-18 h/day, depending on the geographic location and season of the year (23)(24)(25). Reductions in body weight, relative FM and resting metabolic rate are common consequences of Ramadan IF (20,26). It has also been shown that Ramadan-related caloric restriction decreases total cholesterol, low-density lipoprotein (LDL) and fasting blood glucose levels. In parallel, Ramadan IF seems to improve body composition, possibly through enhancements in the ability to mobilize saturated fatty acids for metabolic processes (25). Changes in body composition may also reflect a balance between the unavoidable decrease of meal frequency (i.e., from 3-4 to 2) and sleep duration, together with a reduction of spontaneous daily physical activity and coercive dehydration (27)(28)(29). However, the effects of Ramadan IF on body composition are not conclusive, with some studies indicating significant reductions in body weight (19,20,23,24,26,28,(30)(31)(32)(33)(34) and many other failing to show any relevant changes (21,22,27,(35)(36)(37)(38)(39)(40). Such inconsistencies might be secondary to the specificities inherent to the participants included in each study. Alternatively, they may be dependent on differences between studies at the level of macro and micronutrient intake, or even arise as a consequence of cultural rituals or the number of fasting hours (23).
Taking all these points into consideration, this systematic review and meta-analysis aimed at summarizing the existing evidence on the effect of various IF regimens (i.e., TRF, ADF, IER, and Ramadan IF) on body composition. In addition, we sought to determine whether Ramadan and non-Ramadan IF exert a differential impact on human body composition. We hypothesized that various types of IF might contribute for improving body composition and that this effect might be further enhanced in circumstances compatible with a non-Ramadan dietary approach. To our knowledge, this is the first study providing such a comprehensive perspective.

METHODS
This systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement (41) and is registered on PROSPERO (registration number CRD42020191161).

Eligibility Criteria
Articles focusing on the interaction between IF and body composition outcomes were retrieved. Only original research published in peer-reviewed scientific journals were considered. Studies were selected for this review if they respected the Frontiers in Nutrition | www.frontiersin.org following criteria: (i) included samples of adults (≥18 years), regardless of sex, (ii) had an experimental or observational design, (iii) investigated any type of IF (i.e., TRF, ADF, IER, or Ramadan IF), and (iv) included body composition outcomes (i.e., body weight, FFM, FM, muscle mass/volume, bone density, waist circumference, or body mass index-BMI). Studies including persons with specific health conditions, taking medication or having diseases/conditions known to affect metabolism/body composition (e.g., cancer, thyroid disease, diabetes, bariatric surgery, total parenteral nutrition, human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), organ transplant, Prader-Willi Syndrome, polycystic ovary syndrome, chronic obstructive pulmonary disease, or acute illnesses, such as infections or traumatic injury), or pregnant women (or breastfeeding) were not included. Review articles, case studies, protocols, as well as abstracts/conference papers were also excluded.

Search Strategy
A comprehensive search of peer-reviewed articles was conducted in May 2020 in the following electronic databases: PubMed, Scopus and Web of Science. Searches included combinations of two sets of terms: (i) terms concerning the dietary intervention (i.e., IF) and (ii) terms representing the outcome of interest (i.e., body composition). Free-text terms used for the literature search were as follows (based on keywords): ("intermittent fasting" OR "alternate-day-fasting" OR "time-restricted feeding" OR "timerestricted eating" OR "periodic fasting" OR "intermittent calorie restriction" OR "intermittent energy restriction" OR "fasted state" OR "Ramadan") AND ("body composition" OR "body mass" OR "body mass index" OR "Quetelet index" OR "fatfree mass (FFM)" OR "fat-free mass" OR "fat mass" OR "fat percentage" OR "body weight" OR "waist circumference" OR "muscle mass" OR "muscle volume" OR "bone density"). There were no restrictions regarding the language of publication. Additionally, manual cross-referencing of literature cited in previous key reviews were performed.

Screening and Data Extraction
All titles and abstracts identified from the literature searches were screened for potential inclusion eligibility by three authors (JC, IS and GVM), based on the eligibility criteria mentioned above. Duplicate entries were removed. Relevant studies were fully screened by the same authors. A data extraction form was developed to compile information about the article (i.e., authors and year of publication), participants (i.e., sample size and demographics), study design, intervention characteristics (i.e., methods, protocols and length of intervention), and outcomes of interest. Endnote R X7 for Windows 10 was used to manage the references. The first author (JC) extracted the data and uncertainties were resolved by consensus.

Quality Assessment
Study quality was assessed with the Quality Assessment Tool for Quantitative Studies developed by the Effective Public Health Practice Project (EPHPP) (42), evaluating five key methodological domains: selection bias, study design, confounders, data collection method and withdrawals/dropouts. Since it is not possible to blind participants regarding a fasting condition, the sixth item of the original scale (blinding) was not assessed. Each domain was classified as strong, moderate or weak methodological quality. A global rating was determined based on the scores of each component. The five domains and overall quality were rated independently by two authors (JC and IS), and discrepancies were discussed until a consensus was reached. Inter-rater agreement across categories varied from moderate (Cohen's k = 0.6) to strong (k = 1).

Data Synthesis
For each study, results were summarized by: (i) intervention characteristics (intervention protocols, methods and duration), (ii) changes in body weight, (iii) changes in BMI, (iv) changes in absolute and relative FM, and (v) changes in FFM.

Data Analysis
Analyses were conducted using the Comprehensive Meta-Analysis (CMA) software version 3.0 (43). Separate metaanalyses were performed for each outcome (BMI, FM, FFM, and body weight) considering all studies, only Ramadan IF and only non-Ramadan IF studies. Meta-analyses were conducted using both random-effects and fixed-effect models, in which the summary effect size (ES) is the standardized mean difference (SMD) of a distribution (44,45). Random-effects models were chosen for most analyses due to the high number of available studies (k ≥ 6), assuming that the true effect size varies from study to study and that the studies in our analysis represent a random sample of effect sizes. When the number of studies per outcome was limited (k < 6), we used fixed-effect models, assuming that the true effect size is the same in all studies and the only reason for the effect size to vary between studies is sampling error (44). SMDs were calculated based on sample size, standard differences in means (between pre-and postintervention time points and between pre-and post-intervention data of both treatment and control groups) and effect direction, and were interpreted according to Cohen's guidelines, with values of 0.2, 0.5 and 0.8 for small, medium and large SMD, respectively (46). The 95% confidence interval (CI) and corresponding pvalues were considered as indicators of statistical significance. To evaluate the amount of variation in the effects of included studies, we tested for heterogeneity using the following approach: (i) the Cochran's Q statistic (47), for which a significant p-value (<0.05) demonstrates that studies do not share a common SMD (i.e., there is heterogeneity in the effect sizes between studies); and (ii) the I 2 statistic (48) that assesses the proportion of observed dispersion that is due to real differences in the actual SMD and is not affected by low statistical power. The I 2 ranges from 0 to 100%, where a value of 0% indicates no observed heterogeneity and values of 25, 50, and 75% reflect low, moderate and high heterogeneity, respectively (48). Some studies did not provide sufficient data to estimate the SMD and therefore the number of studies per outcome reported in the qualitative synthesis may differ from the ones included in the meta-analyses.
Subgroup analyses were conducted to examine whether the effect of IF on body composition outcomes varied according to the pre-intervention nutritional status (overweight/obesity vs. normal body weight), exercise (protocols with vs. without exercise), and caloric intake (controlling for vs. not controlling for caloric intake). These subgroup analyses were conducted using mixed-effect models (i.e., random-effects model was conducted within subgroups and a fixed-effect model was used across subgroups) (49). Between-groups Q statistic and corresponding p-values were used to compare the mean effect across subgroups. Some studies included samples with both individuals showing normal body weight and excess weight/obesity, and therefore could not be included in moderation analyses.

Sensitivity Analyses
Sensitivity analyses were carried out to explore if the results were affected by methodological quality. Therefore, primary analyses were repeated excluding studies with poor methodological quality. Publication bias was also examined by visual inspection of funnel plots for asymmetry. To quantitatively confirm the visual impression, Egger's test (50) and Duval and Tweedie's trim-and-fill method (51) were used, but only for meta-analyses with 10 or more studies per outcome and no substantial heterogeneity, since the power is too low to distinguish chance from real asymmetry.

Study Selection
PubMed, Scopus and Web of Science searches generated 8,785 publications. Two publications were manually added from previous key reviews. Of 4,771 articles (after duplicates were removed), 124 were considered potentially relevant. Sixty-six articles met all inclusion criteria and were included in the present review (Figure 1). Of these, 60 provided sufficient data to be included in the meta-analyses.

Study Characteristics
Characteristics of included studies are summarized in Supplementary Table 1. Twenty-seven studies were randomized controlled trials, 13 studies were non-randomized controlled trials, four studies were quasi-experimental (i.e., used a singlegroup pre-post-test design, where participants were their own controls) and 22 were observational studies. All IF protocols were conducted in laboratories (k = 66). More than half were undertaken during the month of Ramadan (k = 34) and the others explored the effects of TRF vs. normal diet on body composition (k = 12), during a period of 12 weeks (k

Quality Assessment
Supplementary Table 2 shows the detailed classification of each quality domain and the overall methodological quality of each study. Of the 66 studies identified as relevant for this systematic review, the overall methodological quality of 40 studies was rated as "moderate" and 26 were classified as "weak." Twenty-seven studies (randomized controlled trials) were rated as strong and 13 (non-randomized controlled trials) were rated as moderate regarding the quality of study design; the remaining studies were rated as weak. All studies (k = 66) were classified as weak regarding selection bias (representativeness) because the samples were self-selected or composed by volunteers. With regard to the adjustment of analyses for confounders, all studies (k = 66) were classified as strong because there was no bias arising from lack of controlled elements. In what concerns data collection methods, all studies were rated as strong because they all used valid and reliable tools. Finally, regarding the reporting of withdrawals and dropouts, 20 studies were rated as strong, 19 studies were rated as moderate, and one study was rated as weak.

Effects of Intermittent Fasting on Specific Outcomes
A data analytic synthesis of the effects of IF on the four tested body composition outcomes (i.e., body weight, BMI, absolute and relative FM, and FFM) is shown in Supplementary Table 1. Table 1 shows the meta-analytic results for the pooled estimates of these effects, and Figures 2-6 the respective forest plots. Tables 2-4 show the moderation effect of nutritional status, exercise and caloric control, respectively, on these estimates.

Changes in Body Weight
Sixty-four studies reported effects of IF on body weight, with ∼66% of them attaining significant changes in this specific outcome. Some studies obtained significant decreases in body There was evidence of publication bias based on the visual inspections of the funnel plots for body weight, when comparing pre-post data between treatments and controls including all studies and non-Ramadan IF studies only, and when considering pre-post intervention data only for all studies, but due to the moderate-to-high heterogeneity observed, there was not enough power to differentiate chance from real asymmetry. There was evidence of publication bias based on the visual inspection of the funnel plots, but due to the large heterogeneity observed including all studies and non-Ramadan IF studies FIGURE 5 | Forest plot of the effects from a random-effects and fixed-effects, respectively, meta-analysis shown as standardized mean difference with 95% confidence intervals on relative fat mass (FM) for all studies and only Ramadan IF studies. For each study, the square represents the standardized mean difference between pre-post data intervention and control groups, with the horizontal line intersecting it as the lower and upper limits of the 95% confidence interval. Forest plot of the effects from a random-effects and fixed-effects, meta-analysis shown as standardized mean difference with 95% confidence intervals on relative FM for all studies, only Ramadan IF studies and only non-Ramadan IF studies. For each study, the square represents the standardized mean difference between pre-and post-intervention time points. The rhombi represents the pooled estimated standardized mean difference. *Pre-post tests, IF intervention; **Pre-post tests, IF intervention vs. control.
only, there was not enough power to differentiate chance from real asymmetry.
Subgroup analyses showed that exercise moderated the effect of IF on BMI when comparing pre-post-intervention data between non-Ramadan IF treatments and the control groups (Q  Sensitivity analyses showed that, when excluding the studies with poor quality, the effect of Ramadan IF interventions on relative FM became non-significant (p > 0.05).

Changes in Fat Mass
Regarding publication bias, visual inspections of the funnel plots for absolute FM showed the presence of asymmetry between all studies and between non-Ramadan IF studies only, when comparing pre-post-intervention data between treatments and controls, and between all studies when considering pre-postintervention data only. Visual inspections of the funnel plots for relative FM also demonstrated asymmetry between all studies, when considering pre-post-intervention data only. However, due to the moderate-to-high heterogeneity observed, there was not enough power to differentiate chance from real asymmetry.
Subgroup analyses showed that, when considering pre-postintervention data for all studies, there were significant differences in the effect of IF on absolute and relative FM between studies with and without caloric control (absolute FM: Q = 49.961, p Regarding publication bias, visual inspections of the funnel plots did not show the presence of asymmetry, which was confirmed with Egger's tests (p > 0.05).
Subgroups analyses revealed significant differences in the effect of IF on FFM between individuals with normal weight and overweight, when considering pre-post-intervention data for all studies (Q = 4.142, p = 0.042), although changes in each subgroup were not significant (p > 0.05). Significant differences in the effect of IF on FFM between studies with and without caloric control were also found, when considering pre-post-intervention data for all studies (Q = 13.365, p < 0.001): a small positive effect was found when caloric Frontiers in Nutrition | www.frontiersin.org

DISCUSSION
This study sought to summarize the effects of different IF approaches on body composition-related outcomes. To our knowledge, this is the first systematic review and meta-analysis presenting comprehensive results on changes in specific parameters of body composition resulting from Ramadan vs. non-Ramadan IF, which is of considerable relevance given the recent popularity of these approaches among researchers and clinical nutritionists/sports physiologists. Our findings showed that, when comparing pre-with post-intervention data between treatment and control groups, Ramadan IF elicits significant reductions in some body composition parameters, namely in relative FM and body weight. Similar results were also found when considering pre-to postintervention (within-subjects design); specifically, data indicated that Ramadan IF leads to significant reductions in BMI, FM (relative and absolute), and body weight. Our findings also suggest that, with Ramadan IF, weight loss seems to be more pronounced in persons exhibiting higher BMI values, although there were no significant differences between groups (normal weight vs. overweight/obesity). These findings are in line with those of past research (30). A greater loss of body fluids in individuals with overweight/obesity during Ramadan IF offers a likely explanation for such relationships (52).
In the general population, weight loss subsequent to Ramadan IF is largely caused by the unconscious restriction of food intake. Under these circumstances, the reduction in meal frequency is causally linked with the prolonged daily periods of standing and praying (19,24,26,31,32,36). In addition, there is a metabolic shift toward the predominant use of fatty acids as fuel for adenosine triphosphate (ATP) synthesis during Ramadan IF and this lowers body fat (25). The optimization of energy reserves during this type of IF may also serve as a possible explanation for this phenomenon. According to this concept, while being effective in preserving protein pools via a reduction in basal metabolism, Ramadan IF also leads to a decreased secretion of anabolic hormones (e.g., insulin) and an increased secretion of catabolic hormones (i.e., adrenaline and glucagon) (53). Interestingly, it has been contended that weight loss resulting from Ramadan IF is also accompanied by reductions in FFM (>35% in normoponderal people and ∼20-30% in those with overweight/obesity) (54). Our meta-analytic findings do not support this contention, revealing no significant effects of Ramadan IF on FFM. From a physiological standpoint, this is a relevant finding because FFM is well-known to play an important role on functional capacity, resting energy expenditure and blood glucose homeostasis (55). However, despite representing an important opportunity for some people to lose body weight and FM, the adaptations inherent to Ramadan IF are typically transient and largely reversible within a small amount of      time (26). Thus, the prescription of maintenance strategies at termination of Ramadan is of extreme value for the long-term preservation of healthy body composition. Caloric restriction and different forms of fasting are wellknown to exert a powerful physiological impact on humans, namely on health status and body composition (5). According to our analyses, more than half of the studies (pre-post-intervention within-subjects design) examining the effects of non-Ramadan IF on FFM revealed small, but significant improvements in FFM. TRF was shown to be particularly effective in inducing slight increases in FFM [e.g., (17,56)]. In fact, it has been argued that, when combined with resistance training, TRF has an adjunctive role in preserving or delaying possible FFM losses (3,57). Moreover, fasting triggers numerous endocrine responses that may well contribute for heightened metabolic rate and preserved FFM (e.g., increased serum levels of noradrenaline and growth hormone, respectively) (58). In addition, exercising while fasting increases the expression of sirtuin 1 (SIRT1) as well as the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), both of which have numerous effects on gene expression (i.e., regulation of mitochondrial biogenesis) (59). Yet, it has been disputed whether the interaction between TRF and gains in FFM might be mediated by the amount of dietary protein intake, together with the final energy balance achieved on a daily basis (3,60). This is partially supported by our moderation analyses because, when calorie consumption was taken into consideration, a significant effect of IF on FFM emerged. In addition, when comparing pre-post-intervention data between treatment and control groups, the beneficial effects of IF on decreasing BMI were more pronounced after accounting for exercise training. Non-Ramadan IF also led to significant reductions in body weight and absolute FM when comparing prepost-intervention data between treatment and control groups, as well as when comparing pre-post-intervention on withinsubjects designs. In fact, studies specifically designed to test the effects of IF on body composition have consistently shown that different approaches of IF (i.e., ADF, IER, and TRF) are well-suited for managing successful losses in body weight and FM (2,10,13,61). One possible explanation is that 12 h of fasting generate a lipolytic-prone state that is compatible with decreased fat storage and enhanced fatty acid mobilization, together with ketogenesis (62). Moreover, in the short term, non-Ramadan IF (i.e., ADF protocol 5:2) appears to be superior (due to higher compliance) than CER for reducing FM (61).
According to the present beliefs, Ramadan IF is more effective for weight loss than non-Ramadan IF due to a greater loss of body water resulting from fluid deprivation (53). Although the opposite was found when considering our meta-analytical results involving pre-post-intervention analyses (within-subjects designs) (i.e., higher effects derived from non-Ramadan IF), similar results were observed for Ramadan vs. non-Ramadan IF interventions when comparing treatments and controls. However, there are clear differences in what concerns to absolute FM, with non-Ramadan IF showing greater improvements in this specific parameter, therefore being unequivocally linked to improved body composition.
This study has some limitations. First, our findings should be interpreted with caution because analyses were carried out on different populations. Second, since we did not include individuals from all ages, ethnicities, religions, geographical areas and educational backgrounds, our findings cannot be extrapolated to the general population. Third, the degree of calorie restriction varied between studies and the nonfasting control groups also ranged from "normal diet" to CER. Fourth, the nutritional profile of foods consumed during the ad libitum feeding period should be further monitored. Fifth, the analyses of body composition were made with different techniques and, due to the limited number of studies per technique, it was not possible to conduct moderation analyses. Bioimpedance, a technique that assumes individual euhydration, was used in many studies. Since Ramadan IF is typically accompanied by dehydration, in this specific context, the assessments of body composition using this method may be affected. The preferable use of gold standard techniques, such as the four-component model or even the single use of dual x-ray absorptiometry (only 16 studies here included used this method) in future research is fundamental. This approach would greatly reduce the possibility of measurement inaccuracies. Finally, it would have been important to discriminate the moderating effects of different types of exercise (e.g., endurance vs. resistance training). However, the low number of studies on each specific type of exercise precluded us from conducting separate moderation analyses. Instead, all exercise studies were compiled and used as a single moderator.
In summary, our meta-analytic findings revealed a negative significant pooled estimate effect of both Ramadan and non-Ramadan IF on FM and body weight. However, we found that decreases in FM are more pronounced with non-Ramadan IF and this type of IF, combined with exercise training, leads to higher decreases in BMI. Our data also provide preliminary evidence that non-Ramadan IF may be wellsuited for eliciting small increases in FFM, particularly under circumstances involving the simultaneous control of caloric intake. Thus, although Ramadan IF certainly implicates some beneficial adaptations in weight management, non-Ramadan IF appears to be more effective in improving overall body composition (particularly, if combined with exercise training and controlled calorie intake), despite the fact it does not imply dehydration.

DATA AVAILABILITY STATEMENT
The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author/s.