AUTHOR=Zhuang Yan , Wang Xinmei , Zhang Xuanrui , Fang Qian , Zhang Xinyi , Song Yan 

TITLE=The relationship between dietary patterns derived from inflammation and cognitive impairment in patients undergoing hemodialysis

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1218592

DOI=10.3389/fnut.2023.1218592

ISSN=2296-861X

ABSTRACT=Introduction: Dietary patterns were shown to be closely related to inflammation, which were independently associated with cognitive impairment (CI) in patients undergoing hemodialysis (HD). However, it remains unclear the influence of dietary pattern derived from inflammation on CI in this population. This study aimed to examine the association between dietary pattern derived from C-reactive protein (CRP) and interleukin-6 (IL-6) and CI in patients undergoing HD.: Dietary intake was obtained from the quantitative simplified food frequency questionnaire. Reduced rank regression (RRR) was used to extract two dietary patterns, with IL-6 and CRP as response variables. Cognitive function was examined by the Montreal Cognitive Assessment (Beijing version). Venous blood was drawn for measuring IL-6 and CRP levels. Multivariable logistic regression was used to investigate the association between dietary patterns and CI.Results: Dietary pattern derived from IL-6 was not significantly associated with CI.The third quartile of dietary pattern which used CRP as the response variable significantly contributed to the increased risk of CI (AOR 8.62, 95%CI 1.47~50.67) after controlling age, sex, education level, marriage status and residential pattern (p-for-trend = 0.028). After taking into account hypertension and diabetes, physical activity level, anxiety and depression, smoking and drinking status, social support, energy intake and dietary pattern derived from IL-6 (p-for-trend = 0.026), the relationship between dietary pattern derived from CRP and CI remained significant (AOR 14.54, 95%CI 1.40~151.13).Dietary pattern associated with high CRP level, including high intake of rice, tea and coffee, liquor and fruit, and low intake of dark vegetables and juice contributed to the increased risk of CI. The association between consumption of seafood, sweet beverages and alcohol and CI has yet to be established. However, they may be dietary contributing factors to inflammation in patients undergoing HD.