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SYSTEMATIC REVIEW article

Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1288832
This article is part of the Research Topic

Nutrition for an Aging Brain

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Association between triglyceride glucose index with cognitive impairment and dementia in adult population: A meta-analysis

Yuqing Han1* Xu Meng2 Dahui Wang1
  • 1The First people's Hospital of Xiaoshan District, China
  • 2Zhejiang Xiaoshan Hospital, China

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The association between insulin resistance (IR) and cognitive dysfunction remains poorly understood. The aim of the systematic review and meta-analysis was to evaluate the relationship between triglyceride glucose (TyG) index, a newly proposed indicator of IR, with cognitive impairment and dementia in adult population.Methods: Observational studies pertinent to our research were identified through comprehensive searches of the PubMed, Embase, and Web of Science databases. To account for potential heterogeneity, the random-effects models were employed to aggregate the findings.Results: Ten observational studies including 5602409 participants were included.Compared to those with the low TyG index, subjects with the high TyG index were significantly associated with the risk of cognitive impairment (risk ratio [RR]: 1.39, 95% confidence interval [CI]: 1.22 to 1.59, p < 0.001; I 2 = 45%) and dementia (RR: 1.30, 95% CI: 1.06 to 1.60, p = 0.01; I 2 = 50%). The association was consistent for Alzheimer's disease (RR: 1.35, 95% CI: 1.04 to 1.76, p = 0.03; I 2 = 54%) and vascular dementia (RR: 1.18, 95% CI: 1.13 to 1.24, p < 0.001; I 2 = 0%). Subgroup analyses showed that the association between TyG index with cognitive impairment and dementia were stronger in cross-sectional studies than that in cohort studies (p for subgroup difference = 0.02), but not significantly affected by age, sex, or diabetic status of the participants.A high TyG index may be associated with higher risk of cognitive impartment and dementia in adult population.

Keywords: Triglyceride glucose index, Insulin, cognitive impairment, Dementia, Meta-analysis

Received: 06 Sep 2023; Accepted: 18 Jan 2024.

Copyright: © 2024 Han, Meng and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Yuqing Han, The First people's Hospital of Xiaoshan District, Hangzhou, China