AUTHOR=Riva Laura , Luzi Lucilla , Pelicci Pier Giuseppe 

TITLE=Genomics of Acute Myeloid Leukemia: The Next Generation

JOURNAL=Frontiers in Oncology

VOLUME=Volume 2 - 2012

YEAR=2012

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2012.00040

DOI=10.3389/fonc.2012.00040

ISSN=2234-943X

ABSTRACT=Acute myeloid leukemia (AML) is, as other types of cancer, a genetic disorder of somatic cells. The detection of somatic molecular abnormalities that may cause and maintain AML is crucial for stratifying patients. The development of mutation-specific therapeutic interventions will hopefully increase cure rates and improve patients’ quality of life. This mini-review illustrates how next generation sequencing (NGS) technologies are changing the study of cancer genomics of adult AML patients.