TY - JOUR AU - Hernandez, Brenda AU - Goodman, Marc AU - Unger, Elizabeth AU - Steinau, Martin AU - Powers, Amy AU - Lynch, Charles AU - Cozen, Wendy AU - Saber, Maria AU - Peters, Edward AU - Wilkinson, Edward AU - Copeland, Glenn AU - Hopenhayn, Claudia AU - Huang, Youjie AU - Watson, Meg AU - Altekruse, Sean AU - Lyu, Christopher AU - Saraiya, Mona PY - 2014 M3 - Original Research TI - Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based United States population JO - Frontiers in Oncology UR - https://www.frontiersin.org/articles/10.3389/fonc.2014.00009 VL - 4 SN - 2234-943X N2 - Background: Human papillomavirus (HPV) is estimated to play an etiologic role in 40–50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited.Methods: HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patients diagnosed in 1998–2005 within the catchment areas of seven U.S. cancer registries. HPV was genotyped using PCR-based Linear Array and INNO-LiPA assays and compared by demographic, clinical, and pathologic characteristics and survival. Histological classification was also obtained by independent pathology review.Results: HPV DNA was present in 50 of 79 (63%) of invasive penile cancer cases. Sixteen viral genotypes were detected. HPV 16, found in 46% (36/79) of all cases (72% of HPV-positive cases) was the most prevalent genotype followed equally by HPV 18, 33, and 45, each of which comprised 5% of all cases. Multiple genotypes were detected in 18% of viral positive cases. HPV prevalence did not significantly vary by age, race/ethnicity, population size of geographic region, cancer stage, histology, grade, penile subsite, or prior cancer history. Penile cases diagnosed in more recent years were more likely to be HPV-positive. Overall survival did not significantly vary by HPV status.Conclusion: The relatively high prevalence of HPV in our study population provides limited evidence of a more prominent and, possibly, increasing role of infection in penile carcinogenesis in the U.S. compared to other parts of the world. ER -