AUTHOR=Vetro Calogero , Romano Alessandra , Ancora Flavia , Coppolino Francesco , Brundo Maria V. , Raccuia Salvatore A. , Puglisi Fabrizio , Tibullo Daniele , La Cava Piera , Giallongo Cesarina , Parrinello Nunziatina L. TITLE=Clinical Impact of the Immunome in Lymphoid Malignancies: The Role of Myeloid-Derived Suppressor Cells JOURNAL=Frontiers in Oncology VOLUME=5 YEAR=2015 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2015.00104 DOI=10.3389/fonc.2015.00104 ISSN=2234-943X ABSTRACT=

The better definition of the mutual sustainment between neoplastic cells and immune system has been translated from the bench to the bedside acquiring value as prognostic factor. Additionally, it represents a promising tool for improving therapeutic strategies. In this context, myeloid-derived suppressor cells (MDSCs) have gained a central role in tumor developing with consequent therapeutic implications. In this review, we will focus on the biological and clinical impact of the study of MDSCs in the settings of lymphoid malignancies.