@ARTICLE{10.3389/fonc.2017.00038, AUTHOR={Melosky, Barbara}, TITLE={Current Treatment Algorithms for Patients with Metastatic Non-Small Cell, Non-Squamous Lung Cancer}, JOURNAL={Frontiers in Oncology}, VOLUME={7}, YEAR={2017}, URL={https://www.frontiersin.org/articles/10.3389/fonc.2017.00038}, DOI={10.3389/fonc.2017.00038}, ISSN={2234-943X}, ABSTRACT={The treatment paradigm for metastatic non-small cell, non-squamous lung cancer is continuously evolving due to new treatment options and our increasing knowledge of molecular signal pathways. As a result of treatments becoming more efficacious and more personalized, survival for selected groups of non-small cell lung cancer (NSCLC) patients is increasing. In this paper, three algorithms will be presented for treating patients with metastatic non-squamous, NSCLC. These include treatment algorithms for NSCLC patients whose tumors have EGFR mutations, ALK rearrangements, or wild-type/wild-type tumors. As the world of immunotherapy continues to evolve quickly, a future algorithm will also be presented.} }