AUTHOR=Dooley James , Lagou Vasiliki , Pasciuto Emanuela , Linterman Michelle A. , Prosser Haydn M. , Himmelreich Uwe , Liston Adrian TITLE=No Functional Role for microRNA-342 in a Mouse Model of Pancreatic Acinar Carcinoma JOURNAL=Frontiers in Oncology VOLUME=7 YEAR=2017 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2017.00101 DOI=10.3389/fonc.2017.00101 ISSN=2234-943X ABSTRACT=
The intronic microRNA (miR)-342 has been proposed as a potent tumor-suppressor gene. miR-342 is found to be downregulated or epigenetically silenced in multiple different tumor sites, and this loss of expression permits the upregulation of several key oncogenic pathways. In several different cell lines, lower miR-342 expression results in enhanced proliferation and metastasis potential, both