AUTHOR=Baptista Renata Lyrio Rafael , dos Santos Anna Cláudia Evangelista , Gutiyama Luciana Mayumi , Solza Cristiana , Zalcberg Ilana Renault 

TITLE=Familial Myelodysplastic/Acute Leukemia Syndromes—Myeloid Neoplasms with Germline Predisposition

JOURNAL=Frontiers in Oncology

VOLUME=7

YEAR=2017

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2017.00206

DOI=10.3389/fonc.2017.00206

ISSN=2234-943X

ABSTRACT=<p>Although most cases of myeloid neoplasms are sporadic, a small subset has been associated with germline mutations. The 2016 revision of the World Health Organization classification included these cases in a myeloid neoplasm group with a predisposing germline mutational background. These patients must have a different management and their families should get genetic counseling. Cases identification and outline of the major known syndromes characteristics will be discussed in this text.</p>