Original Research ARTICLE
Cohort Profile: The Danish Testicular Cancer Late Effects Cohort (DaTeCa-LATE)
- 1Department of Oncology 5073, Rigshospitalet, Denmark
- 2Centre for Health, Research Centre for Prevention and Health, Denmark
- 3Department of Oncology, Aarhus University Hospital, Denmark
- 4Department of Oncology, Odense University Hospital, Denmark
- 5Unit of Survivorship, Danish Cancer Society Research Center, Danish Cancer Society, Denmark
The cohort was set up in order to analyse late effects in long-term testicular cancer survivors (TCS) and to contribute to the design of future follow-up programs addressing and potentially preventing late effects.
Data for this cross-sectional study was collected between 1 January 2014 and 31 December 2016 among living Danish TCS and 60% agreed to participate in the cohort (N = 2572). Mean time since testicular cancer diagnosis was 18 years (range 7-33) and mean age of participants was 53 years (range 25-95).
Data consists of results of a questionnaire with patient reported outcomes which covers a broad range of items on late-effects. The study also included data obtained through linkages to Danish registries, a biobank, and clinical data from hospital files and pathology reports originating from the Danish Testicular Cancer Database (DaTeCa).
The treatment during the observation period has been nearly the same for all stages of TC and is in agreement with today’s standard treatment, this allows for interesting analysis with a wide timespan. We have extensive data on non-responders and are able to validate our study findings. Data from a Danish reference population (N = 162 283) allows us to compare our findings with a Danish background population. The cohort can easily be extended to access more outcomes, or include new TCS.
A limitation of the present study is the cross-sectional design and despite the large sample size, DaTeCa-LATE lacks statistical power to study very rare late effects. Since it was voluntary to participate in the study we have some selection bias, for instance we lack responders who were not in a paired relationship, but we would still argue that this cohort of TCSs is representative for TCSs in Denmark.
Collaboration and data access: Researches interested in collaboration with the DaTeCa-LATE study group please contact Professor Gedske Daugaard firstname.lastname@example.org.
Keywords: testicular cancer, Germ cell cancer, cohort profile, cohort study, Cancer late effects, late effects
Received: 07 Dec 2017;
Accepted: 01 Feb 2018.
Edited by:Dana Hashim, International Agency For Research On Cancer (IARC), France
Reviewed by:Lital Keinan-Boker, University of Haifa, Israel
Prerna Khetan, Icahn School of Medicine at Mount Sinai, United States
Marta Manczuk, Maria Sklodowska Curie Institute of Oncology, Poland
Copyright: © 2018 Kreiberg, Bandak, Lauritsen, Skøtt, Johansen, Agerbaek, Holm, Johansen and Daugaard. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: MD. Michael Kreiberg, Rigshospitalet, Department of Oncology 5073, Blegdamsvej 9, Copenhagen, 2100, KBH Ø, Denmark, email@example.com