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Case Report ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2018.00534

Co-occurrence of dermatomyositis and polycythemia unveiling rare de novo neuroendocrine prostate tumor

Charalampos Papagoras1,  Stella Arelaki2, Ioannis Botis1, Ioannis Chrysafis3, Stavros Giannopoulos4 and  Panagiotis Skendros1*
  • 1First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Greece
  • 2Department of Pathology, University Hospital of Alexandroupolis, Democritus University of Thrace, Greece
  • 3Department of Radiology, University Hospital of Alexandroupolis, Democritus University of Thrace, Greece
  • 4Department of Urology, University Hospital of Alexandroupolis, Democritus University of Thrace, Greece

We present a case of dermatomyositis together with polycythemia as initial manifestations of a particularly rare type of prostate cancer. A 69-year-old man was hospitalized for facial erythema and symptoms of fatigue. Physical evaluation, serum creatinine phosphokinase and electromyography were consistent with dermatomyositis. In parallel, the hemoglobin level was 18.5g/dL, serum erythropoietin levels were low normal and no JAK2 mutation was found. Given a strong suspicion of a paraneoplastic syndrome the patient underwent abdominal computed tomography revealing a prostate mass, enlarged iliac lymph nodes and a fracture of L1 due to metastasis. The unusual paraneoplastic manifestations prompted a more thorough immunohistologic examination of the needle biopsy specimen taken from the prostate, which led to the diagnosis of large cell neuroendocrine prostate carcinoma. It is a most rare type of prostate cancer, carrying a poor prognosis. To our knowledge, this is the first case in the literature associating a neuroendocrine cancer of the prostate with dermatomyositis.

Keywords: prostate 
cancer, neuroendocrine neoplasia, Dermatomyositis, Polycythemia, Erythrocytosis

Received: 22 Sep 2018; Accepted: 30 Oct 2018.

Edited by:

Fabio Grizzi, Humanitas Research Hospital, Italy

Reviewed by:

SAZZAD HASSAN, School of Medicine, Indiana University Bloomington, United States
Mohamed S. Zaghloul, National Cancer Institute, Cairo University, Egypt  

Copyright: © 2018 Papagoras, Arelaki, Botis, Chrysafis, Giannopoulos and Skendros. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Panagiotis Skendros, First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece, pskendro@med.duth.gr