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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2018.00642

Elevated Neutrophil to lymphocyte ratio predicts poor prognosis in non-muscle invasive bladder cancer patients: Initial intravesical Bacillus Calmette-Guerin treatment after transurethral resection of bladder tumor setting

Hyeong Dong Yuk1, Chang Wook Jeong2, Cheol Kwak2, Hyeon Hoe Kim2 and  Ja Ku2*
  • 1Department of Urology, Inje University Sanggye Paik Hospital, South Korea
  • 2Department of Urology, College of Medicine, Seoul National University, South Korea

The study investigated the pretreatment systemic inflammatory response (SIR) markers of patients who underwent initial intravesical treatment for high-risk non-muscle invasive bladder cancer (NMIBC).385 patients who underwent initial intravesical Bacillus Calmette-Guerin treatment after transurethral resection of bladder tumor were included. We analyzed the relationship between ratio of SIR markers, such as neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR) and platelet-to-lymphocyte ratio (PLR), and oncological outcomes. Each SIR marker was used for analysis by determining the cut-off value through receiver operation characteristics curves analysis. Patients were divided into two groups according to pretreatment NLR (<1.5 vs ≥1.5), dNLR (<1.2 vs ≥1.2) and PLR values (171

Keywords: BCG, Bladder cancer, neutrophil-to-lymphocyte ratio (NLR), Systemic inflammatory response (SIR), Non-muscle invasive bladder cancer (NMIBC)

Received: 14 Sep 2018; Accepted: 06 Dec 2018.

Edited by:

Fabio Grizzi, Humanitas Research Hospital, Italy

Reviewed by:

Felix K. Chun, University Medical Center Hamburg-Eppendorf, Germany
Naokazu Ibuki, Osaka Medical College, Japan  

Copyright: © 2018 Yuk, Jeong, Kwak, Kim and Ku. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Ja Ku, Department of Urology, College of Medicine, Seoul National University, Seoul, South Korea, randyku@hanmail.net