AUTHOR=Doglioni Ginevra , Parik Sweta , Fendt Sarah-Maria 

TITLE=Interactions in the (Pre)metastatic Niche Support Metastasis Formation

JOURNAL=Frontiers in Oncology

VOLUME=Volume 9 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00219

DOI=10.3389/fonc.2019.00219

ISSN=2234-943X

ABSTRACT=Metastasis formation is the leading cause of death in cancer patients. Thus, understanding and targeting this process is an unmet need. Crucial steps during the establishment of metastases include the (pre)metastatic niche formation. This process relies on the interaction of the primary tumour with the environment of distant organs (premetastatic niche) and the interaction of cancer cells with their environment when arriving in a distant organ (metastatic niche). Here, we summarize the current knowledge on the interactions in the tumour environment that result in (pre)metastatic niche formation in respect to tumour secreted factors, extracellular matrix, immune as well as stromal cells and the nutrients availability. We further highlight approaches to disrupt these interactions as therapeutic strategy against metastases.