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This article is part of the Research Topic

Lithium and Cancer

Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.00296

Systems Biology Understanding of the Effects of Lithium on Cancer

Weihao Ge1 and  Eric Jakobsson1*
  • 1University of Illinois at Urbana-Champaign, United States

Lithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action. Multiple lines of evidence point to lithium as a significant factor in development of cancer, showing that understanding lithium action is of high importance. In this paper we undertake first steps towards a systems approach by analyzing mutual enrichment between the interactomes of lithium-sensitive enzymes and the pathways associated with cancer. This work integrates information from two important databases, STRING and KEGG pathways. We find that for the majority of cancer pathways the mutual enrichment is many times greater than chance, reinforcing previous lines of evidence that lithium is an important influence on cancer.

Keywords: Cancer, Systems Biology, Lithium - ion, Biochemical Network, pathways affecting cancer

Received: 04 Jan 2019; Accepted: 01 Apr 2019.

Edited by:

Zhi Sheng, Virginia Tech, United States

Reviewed by:

Victor C. Kok, Asia University, Taiwan
Braden C. McFarland, University of Alabama at Birmingham, United States  

Copyright: © 2019 Ge and Jakobsson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Eric Jakobsson, University of Illinois at Urbana-Champaign, Champaign, 61820, Illinois, United States, jake@ncsa.illinois.edu