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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.00690

Chest Magnetic Resonance Imaging decreases Inter-Observer Variability of Gross Target Volume for Lung Tumors

 Laurent Basson1*,  Hajer Jarraya1, Alexandre Escande1, Abel Cordoba1, Rayyan Daghistani1,  David Pasquier1, Thomas Lacornerie1, Eric Lartigau1 and Xavier Mirabel1
  • 1Centre Oscar Lambret, France

Purpose: PET/CT is a standard medical imaging used in the delineation of gross tumor volume (GTV) in case of radiation therapy for lung tumors. However PET/CT could present some limitations such as resolution and standardized uptake value threshold. Moreover chest MRI has shown good potential in diagnosis for thoracic oncology. Therefore, we investigated the influence of chest MRI on inter-observer variability of GTV delineation
Methods and Materials: Five observers contoured the GTV on CT for 14 poorly defined lung tumors during three contouring phases based on true daily clinical routine and acquisition: CT phase, with only CT images; PET phase, with PET/CT; and MRI phase, with both PET/CT and MRI. Observers waited at least one week between each phases to decrease memory bias. Contours were compared using descriptive statistics of volume, coefficient of variation (COV), and Dice similarity coefficient (DSC).
Results: MRI phase volumes (median 4.8 cm3) were significantly smaller than PET phase volumes (median 6.4 cm3, p=0.015), but not different from CT phase volumes (median 5.7 cm3, p=0.30). The mean COV was improved for the MRI phase (0.38) compared to the CT (0.58, p=0.024) and PET (0.53, p=0.060) phases. The mean DSC of the MRI phase (0.67) was superior to those of the CT and PET phases (0.56 and 0.60 respectively; p<0.001 for both).
Conclusions: The addition of chest MRI seems to decrease inter-observer variability of GTV delineation for poorly defined lung tumors compared to PET/CT alone and should be explored in further prospective studies.

Keywords: lung cancer, GTV, Chest MRI, Inter-observer variability, Delineation

Received: 04 Mar 2019; Accepted: 12 Jul 2019.

Edited by:

Matthew Harkenrider, Loyola University Chicago, United States

Reviewed by:

Charles B. Simone, Memorial Sloan Kettering Cancer Center, United States
Bilgin Kadri Aribas, Bülent Ecevit University, Turkey
James W. Snider, School of Medicine, University of Maryland, Baltimore, United States  

Copyright: © 2019 Basson, Jarraya, Escande, Cordoba, Daghistani, Pasquier, Lacornerie, Lartigau and Mirabel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Laurent Basson, Centre Oscar Lambret, Lille, France, l-basson@o-lambret.fr